Aizenberg D, Gur S, Zemishlany Z, Granek M, Jeczmien P, Weizman A
Geha Psychiatric Hospital, Petah Tikva, Israel.
Clin Neuropharmacol. 1997 Jun;20(3):210-4. doi: 10.1097/00002826-199706000-00004.
Sexual dysfunction is commonly encountered in patients treated with antidepressants. The exact mechanism responsible for the sexual impairment is as yet unclear, although activation of the serotonergic system has been implicated. In the present study, we examined the effect of the 5-HT2a/2c and alpha 2 antagonist mianserin in the treatment of patients with sexual dysfunction induced by serotonin reuptake inhibitors (SRIs). Mianserin 15 mg was coadministered to 15 male subjects with new-onset sexual dysfunction who were under treatment with SRIs. Four major domains of sexual activity-desire, erection, orgasm, and satisfaction-were assessed once weekly for 4 weeks. At the end of the study, 9 of the 15 subjects reported a marked improvement in their sexual functioning, 2 reported partial improvement, and only 4 subjects showed no improvement at all. The beneficial effects were prominent in the areas of orgasm and satisfaction and were usually noted within the first and second week of mianserin treatment. The addition of mianserin to the treatment regimen was not associated with either improvement or worsening of the basic psychiatric clinical status. It appears that the coadministration of low-dose mianserin may be an additional option in the treatment of sexual dysfunction induced by SRIs.
性功能障碍在接受抗抑郁药治疗的患者中很常见。尽管血清素能系统的激活被认为与之有关，但导致性功能损害的确切机制尚不清楚。在本研究中，我们研究了5-HT2a/2c和α2拮抗剂米安色林对血清素再摄取抑制剂（SRI）所致性功能障碍患者的治疗效果。对15名正在接受SRI治疗且出现新发性功能障碍的男性受试者联合使用15毫克米安色林。对性活动的四个主要方面——性欲、勃起、性高潮和满意度——每周评估一次，共评估4周。在研究结束时，15名受试者中有9名报告其性功能有显著改善，2名报告有部分改善，只有4名受试者完全没有改善。有益效果在性高潮和满意度方面尤为显著，通常在米安色林治疗的第一周和第二周内就会显现。在治疗方案中添加米安色林与基本精神科临床状态的改善或恶化均无关。低剂量米安色林联合用药似乎可能是治疗SRI所致性功能障碍的另一种选择。
