Labbate L A, Grimes J B, Arana G W
Ralph H. Johnson VA Medical Center, Mental Health Service, Charleston, South Carolina 29401, USA.
Biol Psychiatry. 1998 Jun 15;43(12):904-7. doi: 10.1016/s0006-3223(97)00391-0.
Serotonin reuptake inhibitor (SRI) antidepressants have been associated with sexual dysfunction, though there have been few prospective reports specifically examining this problem. The purpose of this study was to determine if three SRIs affected sexual function in anxiety disorder patients over a 3-month period.
Thirty-one patients were enrolled in a prospective study of the effect of three SRIs, fluoxetine, sertraline, and paroxetine, on five aspects of sexual function: libido, erection/lubrication, orgasm quality, orgasm delay, and sexual frequency. Measurements were made at baseline and at each month on visual analogue scales.
For men and women, orgasm quality was lower and orgasm delay longer at months one, two, and three compared to baseline (p < .01). Erection scores were lower over time, but this change was not statistically significant. Lubrication, libido, and sexual frequency were not appreciably changed over 3 months. A higher rate of anorgasmia was noted in women at months one and two, but this did not achieve significance.
Orgasm appears to be a primary sexual function affected by SRIs.
血清素再摄取抑制剂（SRI）类抗抑郁药与性功能障碍有关，不过专门研究这一问题的前瞻性报告寥寥无几。本研究的目的是确定三种SRI类药物在3个月时间里是否会影响焦虑症患者的性功能。
31名患者参与了一项前瞻性研究，该研究旨在探究三种SRI类药物（氟西汀、舍曲林和帕罗西汀）对性功能五个方面的影响，这五个方面分别为性欲、勃起/润滑、性高潮质量、性高潮延迟和性行为频率。在基线时以及之后的每个月，通过视觉模拟量表进行测量。
与基线相比，男性和女性在第1、2、3个月时性高潮质量较低，性高潮延迟时间较长（p < 0.01）。勃起评分随时间降低，但这一变化无统计学意义。在3个月的时间里，润滑、性欲和性行为频率没有明显变化。在第1和第2个月时，女性无高潮发生率较高，但未达到显著水平。
性高潮似乎是受SRI类药物影响的主要性功能。
