[Formation of antibodies of different classes in salmonelloses and typhoid fever].

A modified method of chromatographic analysis was used to obtain fractions of immunoglobulins classes M, G, and A from the sera of patients suffering from salmonelloses, typhoid fever, and carriers; with the aid of passive hemagglutination test O-, H- and Vi-antibodies were determined in the fractions. In food poisoning of salmonella etiology in adults the antibody formation as a rule occurred by the type of secondary immune response, whereas its intensity depended on the severity of the clinical course of the disease. In case of an uncomplicated affection there was an increase of antibodies of all the three immunoglobulin classes. In formation of prolonged carrier state a deficiency of O-antibodies of the IgM-class was noted; this was, however, combined with the normal production of immunoglobulins of class M of H-antibodies. Immune humoral reaction was practically absent in the transitory carriers.