Macula toxicity after intravitreal amikacin.
作者信息
Seawright A A, Bourke R D, Cooling R J
机构信息
Retinal Service, Royal Brisbane Hospital, Queensland.
出版信息
Aust N Z J Ophthalmol. 1996 May;24(2):143-6. doi: 10.1111/j.1442-9071.1996.tb01569.x.
BACKGROUND
Although intravitreal aminoglycosides have substantially improved visual prognosis in endophthalmitis, macular infarction may impair full visual recovery.
METHODS
We present a case of presumed amikacin retinal toxicity following treatment with amikacin and vancomycin for alpha-haemolytic streptococcal endophthalmitis.
RESULTS
Endophthalmitis resolved with improvement in visual acuity to 6/24 at three months. Fundus fluorescein angiography confirmed macular capillary closure and telangiectasis.
CONCLUSIONS
Currently accepted intravitreal antibiotic regimens may cause retinal toxicity and macular ischaemia. Treatment strategies aimed at avoiding retinal toxicity are discussed.
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