Grateau G, Bachmeyer C, Blanche P, Jouanne M, Tulliez M, Galland C, Sicard D, Séréni D
Service de Médecine Interne, Hôtel-Dieu, Paris, France.
J Infect. 1997 May;34(3):219-25. doi: 10.1016/s0163-4453(97)94227-4.
We report nine cases of haemophagocytic syndrome (HS) in patients with human immunodeficiency virus infection, and review the 17 cases described to date in the literature. In 21 of 26 cases, HS developed during an advanced stage of immunodeficiency. Clinical and haematological signs are not specific in this setting, and the diagnosis relies on histological features, mainly bone marrow examination. An opportunistic infection was associated in three cases and a lymphoid malignancy in two of our nine cases. The role of the human immunodeficiency virus in the occurrence of the HS remains to be defined. The overall prognosis is poor as six of our nine patients died within 12 months of presentation.
我们报告了9例人类免疫缺陷病毒感染患者发生噬血细胞综合征（HS）的病例，并对文献中迄今报道的17例病例进行了回顾。26例中的21例，HS在免疫缺陷晚期发生。在此情况下，临床和血液学体征并无特异性，诊断依赖于组织学特征，主要是骨髓检查。3例伴有机会性感染，我们9例中的2例伴有淋巴系统恶性肿瘤。人类免疫缺陷病毒在HS发生中的作用尚待明确。总体预后较差，我们9例患者中有6例在就诊后12个月内死亡。
