Boulieu R, Gallant C, Silberstein N
Institut des Sciences Pharmaceutiques et Biologiques, Laboratoire de Pharmacie Clinique et d'Evaluation du Médicament, Lyon, France.
J Chromatogr B Biomed Sci Appl. 1997 May 23;693(1):233-6. doi: 10.1016/s0378-4347(97)00037-6.
A selective and sensitive isocratic high-performance liquid chromatographic method for the analysis of acyclovir in human plasma was described. Acid deproteinisation was used as sample treatment. Mean analytical recoveries were higher than 94% at low and high concentrations. The quantification limit was 0.1 mg/l for a plasma volume of 500 microl and precision study exhibits coefficients of variation lower than 5%. The method is suitable for therapeutic monitoring of acyclovir concentrations in organ-transplant recipients.
描述了一种用于分析人血浆中阿昔洛韦的选择性和灵敏的等度高效液相色谱法。采用酸脱蛋白法进行样品处理。低浓度和高浓度下的平均分析回收率均高于94%。对于500微升的血浆体积，定量限为0.1毫克/升，精密度研究显示变异系数低于5%。该方法适用于器官移植受者阿昔洛韦浓度的治疗监测。
