Kato T
Inst., Med. Sci. St.-Marianna Univ. School Med.
Nihon Rinsho. 1997 Jun;55(6):1462-7.
One of the representative immunological disorders in systemic autoimmune diseases is production of autoantibodies. Recent studies were concentrated on B cell epitopes of intranuclear autoantigens using recombinant proteins. They revealed autoepitopes homologous to those on exogenous agents and multiple epitopes, which respectively indicated molecular mimicry and antigen-driven immune responses as a mechanism for autoantibody production. Further, some autoantigens are thought to be catalyzed in a disease-specific manner. These antigen-specific factors would contribute to the autoantibody production, cooperating with antigen-nonspecific factors such as polyclonal B cell activation, overexpression of cytokines and dysfunction of T cells and antigen presenting cells.
系统性自身免疫性疾病中典型的免疫紊乱之一是自身抗体的产生。最近的研究集中于使用重组蛋白研究核内自身抗原的B细胞表位。这些研究揭示了与外源因子上的表位同源的自身表位以及多个表位，这分别表明分子模拟和抗原驱动的免疫反应是自身抗体产生的机制。此外，一些自身抗原被认为是以疾病特异性方式被催化的。这些抗原特异性因素会与抗原非特异性因素如多克隆B细胞激活、细胞因子过表达以及T细胞和抗原呈递细胞功能障碍协同作用，促进自身抗体的产生。
