Misaki Y, Kawahata K
Department of Clinical Immunology, Kyushu University.
Nihon Rinsho. 1997 Jun;55(6):1468-74.
The appearance of autoantibodies to nuclear autoantigens is the hallmark of systemic autoimmune diseases. The mechanism of the autoantibody production has remained elusive, though it is generally accepted that autoantigen-specific T cells drive the production. These autoantigen-specific T cells as well as autoreactive B cells can be found in peripheral blood from healthy people, suggesting that these autoreactive cells are regulated peripherally. In this review dealing with autoantibody production mechanism, the brief introduction of our approach employing mouse genetics is also included.
针对核自身抗原的自身抗体的出现是系统性自身免疫性疾病的标志。尽管普遍认为自身抗原特异性T细胞驱动自身抗体的产生，但自身抗体产生的机制仍不清楚。在健康人的外周血中可以发现这些自身抗原特异性T细胞以及自身反应性B细胞，这表明这些自身反应性细胞在外周受到调控。在这篇关于自身抗体产生机制的综述中，还简要介绍了我们采用小鼠遗传学的研究方法。
