• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

[Pathomechanism of HTLV-I associated arthropathy and the role of tax gene].

作者信息

Hasunuma T

机构信息

Institute of Medical Science, St. Marianna University School of Medicine.

出版信息

Nihon Rinsho. 1997 Jun;55(6):1482-5.

PMID:9200936
Abstract

HTLV-I is known to be a causative agent for adult T cell leukemia. Recent studies revealed this virus is also related to several autoimmune disorders, such as arthropathy, myelopathy and Sjögren's syndrome. We studied etiology of HTLV-I associated arthropathy (HAAP), and found that tax is a causative gene for synovial proliferation and induction of immunogenicity. HTLV-I transgenic mice supported the etiopathological role of tax gene. Our results suggested that HAAP is considered to be a prototype of rheumatoid arthritis, and tax is a best tool for recognizing pathomechanism of rheumatoid arthritis.

摘要

相似文献

1
[Pathomechanism of HTLV-I associated arthropathy and the role of tax gene].
Nihon Rinsho. 1997 Jun;55(6):1482-5.
2
[Molecular pathomechanism of HTLV-I infectious diseases].[人类嗜T淋巴细胞病毒I型感染性疾病的分子发病机制]
Rinsho Byori. 1997 Nov;45(11):1048-56.
3
Ribozyme-based gene cleavage approach to chronic arthritis associated with human T cell leukemia virus type I: induction of apoptosis in synoviocytes by ablation of HTLV-I tax protein.基于核酶的基因切割方法治疗与人类I型T细胞白血病病毒相关的慢性关节炎：通过消除HTLV-I tax蛋白诱导滑膜细胞凋亡
Arthritis Rheum. 1997 Dec;40(12):2118-27. doi: 10.1002/art.1780401205.
4
The human T cell leukemia virus type I-tax gene is responsible for the development of both inflammatory polyarthropathy resembling rheumatoid arthritis and noninflammatory ankylotic arthropathy in transgenic mice.人类I型T细胞白血病病毒tax基因在转基因小鼠中会引发类似类风湿关节炎的炎性多关节病和非炎性强直性关节病。
J Immunol. 1999 Mar 1;162(5):2956-63.
5
HTLV-I arthropathy and Sjögren syndrome.人类嗜T淋巴细胞病毒I型相关性关节炎和干燥综合征
J Acquir Immune Defic Syndr Hum Retrovirol. 1996;13 Suppl 1:S57-62. doi: 10.1097/00042560-199600001-00011.
6
Detection of human T lymphotropic virus type I tax gene in salivary gland epithelium from two patients with Sjögren's syndrome.在两名干燥综合征患者的唾液腺上皮中检测人嗜T淋巴细胞病毒I型tax基因。
Arthritis Rheum. 1993 Oct;36(10):1423-8. doi: 10.1002/art.1780361015.
7
Arthritis syndromes associated with human T cell lymphotropic virus type I infection.与I型人类嗜T细胞病毒感染相关的关节炎综合征
Med Clin North Am. 1997 Jan;81(1):261-76. doi: 10.1016/s0025-7125(05)70514-9.
8
Autoimmunity induction by human T cell leukemia virus type 1 in transgenic mice that develop chronic inflammatory arthropathy resembling rheumatoid arthritis in humans.1型人类T细胞白血病病毒在转基因小鼠中诱导自身免疫，这些小鼠会发展出类似于人类类风湿性关节炎的慢性炎症性关节病。
J Immunol. 1995 Aug 1;155(3):1588-98.
9
Low CD4/CD8 T-cell ratio associated with inflammatory arthropathy in human T-cell leukemia virus type I Tax transgenic mice.人类 T 细胞白血病病毒 I 型 Tax 转基因小鼠中低 CD4/CD8 T 细胞比值与炎症性关节炎相关。
PLoS One. 2011 Apr 1;6(4):e18518. doi: 10.1371/journal.pone.0018518.
10
[Analysis of infiltrating T cells in the affected autoimmune lesions of HTLV-I transgenic rats].[人嗜T淋巴细胞病毒I型转基因大鼠自身免疫病变部位浸润性T细胞的分析]
Hokkaido Igaku Zasshi. 2001 Jan;76(1):35-47.

引用本文的文献

1
Mixed connective tissue disease with interstitial pneumonia in HTLV-1 carrier: case report and review of the literature.人类嗜T淋巴细胞病毒1型携带者合并间质性肺炎的混合性结缔组织病：病例报告及文献复习
Clin Rheumatol. 2004 Dec;23(6):548-51. doi: 10.1007/s10067-004-0955-y.