Edwards D H, Nichols P J
Acta Orthop Scand. 1977;48(3):273-6. doi: 10.3109/17453677708988767.
In 1968 a study was made of the spinal changes in 32 children with multiple congenital abnormalities due to thalidomide. Twenty-eight of these children have been traced and their spinal changes reviewed. Only four patients had normal spines on radiography. In eight children, scoliosis was present and had progressed though it was still of mild degree. Disc and end-plate abnormalities were seen in 14 children, and in some appeared to be progressive, leading to intervertebral fusion.
1968年，对32名因沙利度胺导致多种先天性异常的儿童的脊柱变化进行了研究。其中28名儿童已被追踪，并对其脊柱变化进行了复查。只有4名患者的脊柱X光片显示正常。8名儿童存在脊柱侧弯，且虽仍为轻度但有进展。14名儿童出现椎间盘和终板异常，其中一些似乎在进展，导致椎间融合。
