Jelić S, Jovanović V, Milanović N, Marinković M, Kovcin V, Milosević D, Vlajić M
Institute of Oncology and Radiology, Belgrade, Yugoslavia.
Neoplasma. 1997;44(1):63-8.
The authors report seven cases of Richter's syndrome, i.e. of large-cell non-Hodgkin's lymphoma (NHL) arising in association with chronic lymphocytic leukemia (CLL). Six patients had the recently recognized variant of this syndrome, occurring in patients with previously undiagnosed subclinical CLL. All patients were treated with aggressive chemotherapy and a complete response of large cell NHL was achieved in 4/7. A complete response of NHL was observed in 3 out of 6, and a partial response in 2/6 patients with simultaneous occurrence of subclinical CLL and large cell NHL (response rate 5/6). Our findings might suggest that patients with Richter syndrome occurring in previously undiagnosed subclinical CLL could represent a better prognostic group in the overall population of patients with large cell NHL transformation of CLL.
作者报告了7例里氏综合征病例，即与慢性淋巴细胞白血病（CLL）相关的大细胞非霍奇金淋巴瘤（NHL）。6例患者患有该综合征最近被认识到的变异型，发生于先前未诊断出的亚临床CLL患者中。所有患者均接受了积极化疗，7例中有4例大细胞NHL获得完全缓解。6例中有3例NHL获得完全缓解，6例同时出现亚临床CLL和大细胞NHL的患者中有2例获得部分缓解（缓解率5/6）。我们的研究结果可能提示，在CLL发生大细胞NHL转化的患者总体人群中，发生于先前未诊断出的亚临床CLL的里氏综合征患者可能代表预后较好的一组。
