Biological effects of the immunomodulator beta 1-3D polyglucose are strongly potentiated by conjugation to biodegradable microbeads.
作者信息
Seljelid R, Gao Q, Berge A, Ugelstad J
机构信息
Institute of Medical Biology, University of Tromsø, Norway.
出版信息
Scand J Immunol. 1997 Jun;45(6):683-7. doi: 10.1046/j.1365-3083.1997.d01-448.x.
Abstract
It is demonstrated that the biological effects of the immunomodulator beta 1-3D polyglucose, when covalently linked to polymethacrylate or biodegradable albumin microbeads, are strongly potentiated. The potentiation is recorded as an increased protection effect of the conjugates in Escherichia coli sepsis in mice, and as increased IL-1 production by murine macrophages in vitro.
摘要
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