Siqueira Neto J I, Santos A C, Fábio S R, Sakamoto A C
Departamento de Medicina Clínica da Universidade Federal do Ceará, Fortaleza CE, Brasil.
Arq Neuropsiquiatr. 1996 Dec;54(4):584-9. doi: 10.1590/s0004-282x1996000400006.
The antiphospholipid antibodies (aPLs) are a heterogeneous group of immunoglobulins that have been related with alterations in blood coagulability in recent years. Patients with elevated titers of these antibodies have a high probability to develop thrombotic events, including cerebral infarct (CI). The tests currently used to detect these antibodies are the lupus anticoagulant and ELISA for anticardiolipin antibodies which have a larger proportion of positivity among young patients with CI. In our study we tested 66 patients with cerebral infarcts whose ages ranged from 15 to 40 years for the presence of lupus anticoagulant and anticardiolipin antibodies. The results showed that eleven (16.65%) patients were positive for aPLs and three (4.55%) of them fulfilled the diagnostic criteria for primary antiphospholipid syndrome. These data point out to the importance of investigating aPLs in young patients with CI and its high prevalence in this group compared with healthy population.
抗磷脂抗体（aPLs）是一类异质性免疫球蛋白，近年来已发现其与血液凝固性改变有关。这些抗体滴度升高的患者发生血栓形成事件的可能性很高，包括脑梗死（CI）。目前用于检测这些抗体的试验是狼疮抗凝物和抗心磷脂抗体的酶联免疫吸附测定（ELISA），在年轻的脑梗死患者中阳性比例较高。在我们的研究中，我们检测了66例年龄在15至40岁之间的脑梗死患者是否存在狼疮抗凝物和抗心磷脂抗体。结果显示，11例（16.65%）患者aPLs呈阳性，其中3例（4.55%）符合原发性抗磷脂综合征的诊断标准。这些数据表明，在年轻的脑梗死患者中检测aPLs很重要，而且与健康人群相比，该抗体在这组患者中的患病率很高。
