子宫内接触沙利度胺后肢体畸形儿童的线性生长

Linear growth of children with limb deformities following exposure to thalidomide in utero.

作者信息

Brook C G, Jarvis S N, Newman C G

出版信息

Acta Paediatr Scand. 1977 Nov;66(6):673-5. doi: 10.1111/j.1651-2227.1977.tb07969.x.

DOI:10.1111/j.1651-2227.1977.tb07969.x

PMID:920161

Abstract

The growth of 202 children exposed to thalidomide in utero and having upper (139 children) or lower (63 children) limb deformities has been assess towards the end of pre-pubertal growth. The analyses show that children exposed to thalidomide are shorter than normal children but grow at a normal velocity later. These findings may help in consideration of the mechanism by which thalidomide exerted its teratogenic effect. Analyses of growth may find a wider use in the retrospective assessment of drugs which are potentially harmful in pregnancy.

摘要

对202名在子宫内接触过沙利度胺且有上肢（139名儿童）或下肢（63名儿童）肢体畸形的儿童在青春期前生长期末进行了生长评估。分析表明，接触过沙利度胺的儿童比正常儿童矮，但后期生长速度正常。这些发现可能有助于思考沙利度胺发挥致畸作用的机制。生长分析在对孕期可能有害药物的回顾性评估中可能会有更广泛的应用。