Whyte J, Greenan E
Acta Paediatr Scand. 1977 Nov;66(6):767-75. doi: 10.1111/j.1651-2227.1977.tb07987.x.
The development of epidemiological methods for the study of adverse drug reactions is reviewed in connection with the presentation of data obtained by intensive monitoring of 1 000 admissions to a medical paediatric unit. Compared with adults and American children, the patients received fewer drugs and experienced fewer reactions while in hospital. The drug usage pattern was different from that of American paediatric practice and general practice in the United Kingdom. Fifty-one (6%) patients experienced 119 adverse drug reactions. These occurred more frequently in children suffering from serious disorders and in the majority of cases the basic therapy was continued regardless of the severity of the drug side-effects. Treatment was required for the effects of 66 (55%) adverse reactions. It appears that drug monitoring in paediatric practice may be of greater value if surveillance programmes are designed to provide a "therapeutic audit" and extended to include children receiving drugs in the community.
结合对一家儿科医疗单位1000例住院病例进行强化监测所获得的数据，对药物不良反应研究的流行病学方法发展进行了综述。与成人及美国儿童相比，这些患者住院期间用药较少，不良反应也较少。药物使用模式与美国儿科实践及英国全科医疗不同。51名（6%）患者发生了119例药物不良反应。这些不良反应在患有严重疾病的儿童中更频繁发生，并且在大多数情况下，无论药物副作用的严重程度如何，基本治疗都会继续。66例（55%）不良反应的影响需要进行治疗。如果监测计划旨在提供“治疗审核”并扩展到包括社区中接受药物治疗的儿童，那么儿科实践中的药物监测可能会更有价值。
