Anniko M, Ljungqvist A
Acta Pathol Microbiol Scand A. 1977 Sep;85(5):751-60. doi: 10.1111/j.1699-0463.1977.tb00468.x.
The arsenical compound atoxyl has been used in labyrinthine research because of its documented effects both on cells engaged in an active transport of ions (secretory epithelia) and sensory epithelia (cochlear hair cells and vestibular sensory cells type I and type II.) In the present experiments both the kidney and the structures of the inner ear were studied. The renal tubules were damaged by exposure to atoxyl. Tubular casts, haemorrhages (both in the tubules and in the renal calices) and tubular epithelial cell necrosis occurred. A common denominator in the ototoxic and the nephrotoxic actions of acute atoxyl poisoning might be a disturbance of the very active ion transport systems of the cells involved.
砷化合物阿托克西尔已被用于迷路研究，因为它对参与离子主动转运的细胞（分泌上皮）和感觉上皮（耳蜗毛细胞以及I型和II型前庭感觉细胞）都有已被记录的作用。在本实验中，对肾脏和内耳结构都进行了研究。暴露于阿托克西尔会导致肾小管受损。出现了管型、出血（肾小管和肾盏中均有）以及肾小管上皮细胞坏死。急性阿托克西尔中毒的耳毒性和肾毒性作用的一个共同特征可能是所涉及细胞的非常活跃的离子转运系统受到干扰。
