Sinik Z, Alkibay T, Ataoğlu O, Akyol G, Tokuçoğlu H, Bozkirli I
Department of Urology, Gazi University, School of Medicine, Ankara, Turkey.
Int Urol Nephrol. 1997;29(1):25-31. doi: 10.1007/BF02551413.
Forty-four pathologic specimens of 39 bladder cancer patients were analyzed immunohistochemically with D07 monoclonal antibody to detect over-expression of mutant p53 gene. The findings were interpreted by correlating with patient age, sex, cigarette smoking, number and macroscopic appearance of tumour, histological tumour grade, muscular invasion, vascular invasion, necrosis and urothelial atypia or dysplasia. Mutant p53 gene was over-expressed in 8 (18.2%) specimens. Statistically significant correlation with grade, vascular invasion, necrosis and patient sex was found with p53 over-expression. Available follow-up data were insufficient to draw a conclusion about the prognostic role of p53 over-expression. Prospective studies with larger number of patients are needed to define the exact place of nuclear p53 over-expression in transitional cell bladder cancer.
用D07单克隆抗体对39例膀胱癌患者的44份病理标本进行免疫组化分析，以检测突变型p53基因的过表达。通过与患者的年龄、性别、吸烟情况、肿瘤数量和大体外观、组织学肿瘤分级、肌层浸润、血管浸润、坏死以及尿路上皮异型增生或发育异常进行关联分析来解释研究结果。8份（18.2%）标本中存在突变型p53基因过表达。发现p53过表达与肿瘤分级、血管浸润、坏死及患者性别具有统计学显著相关性。现有的随访数据不足以得出p53过表达预后作用的结论。需要开展更多患者参与的前瞻性研究来明确核p53过表达在移行细胞膀胱癌中的确切地位。
