Brands B, Baskerville J C, Hirst M, Gowdey C W
Pharmacol Biochem Behav. 1979 Sep;11(3):279-82. doi: 10.1016/0091-3057(79)90135-7.
Complex zinc tannate salts of heroin, hydromorphone and l-alpha-acetylmethadol were synthesized and injected in a slow-release vehicle, into rats. One, 3, 7, 10 and 14 days after the drug was administered rats were injected with naloxone hydrochloride (10 mg/kg) and during the following 4 hours body weights, core temperature and behavioral signs such as diarrhea, writhing, teeth chattering and wet dog shakes were recorded. On every naloxone testing day the narcotic-treated groups presented behavioral signs of abstinence, but weight loss and temperature changes were much less consistent. Reduction of core temperature following naloxone administration seems to be an earlier indicator of physical dependence than weight loss. According to the parameters tested a level of physical dependence can persist for at least two weeks after a single injection of these narcotic salts.
合成了海洛因、氢吗啡酮和左旋 - α - 乙酰美沙多的复合锌鞣酸盐，并将其与缓释载体一起注射到大鼠体内。给药后1、3、7、10和14天，给大鼠注射盐酸纳洛酮（10毫克/千克），并在接下来的4小时内记录体重、核心体温以及腹泻、扭体、牙齿打颤和湿狗抖等行为体征。在每个纳洛酮测试日，接受麻醉药物治疗的组都出现了戒断的行为体征，但体重减轻和体温变化不太一致。与体重减轻相比，纳洛酮给药后核心体温的降低似乎是身体依赖的更早指标。根据所测试的参数，单次注射这些麻醉盐后，身体依赖水平至少可持续两周。
