Niv Y, Elkan I, Fraser G M
Department of Gastroenterology, Rabin Medical Center (Beilinson Campus), Petah Tikva, Israel.
Isr J Med Sci. 1997 Jan;33(1):50-2.
Cholinergic urticaria presents as wheals and erythroderma that develop in response to a variety of factors which stimulate muscarinic receptors, including exercise, heat, cold, sweat and emotional stress. We describe a 25-year-old man with ulcerative colitis who developed cholinergic urticaria diagnosed by a metacholine test. He had had seven previous attacks over 8 years, and the finding of elevated liver enzymes required admission to four different hospitals. The clinical picture was identical: urticaria, hepatosplenomegaly, lymphadenopathy and elevation of liver enzymes. The causative agent was never identified and recovery was complete, with or without antibiotic therapy. To the best of our knowledge, this is the first description of liver involvement in cholinergic urticaria noted in the English-language medical literature.
胆碱能性荨麻疹表现为风团和皮肤发红，可由多种刺激毒蕈碱受体的因素诱发，这些因素包括运动、热、冷、出汗和情绪应激。我们报告一例25岁患有溃疡性结肠炎的男性患者，其经乙酰甲胆碱试验诊断为胆碱能性荨麻疹。在过去8年中他曾发作过7次，肝酶升高的情况使他先后入住4家不同医院。临床表现均相同：荨麻疹、肝脾肿大、淋巴结病和肝酶升高。病因从未明确，无论是否接受抗生素治疗，患者均完全康复。据我们所知，这是英文医学文献中首次报道胆碱能性荨麻疹累及肝脏。
