Stein O, Sheinberg B, Schiff E, Mashiach S, Seidman D S
Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Isr J Med Sci. 1997 Jan;33(1):53-8.
The aim of our study was to assess the serologic immunity to cytomegalovirus (CMV) in a population of pregnant women in Israel. We measured the titers of both IgG and IgM to CMV in 6,126 pregnant women by enzyme immunoassay. Of these, 84.3% were found to be positive for anti-CMV IgG and 15.7% were seronegative, and thus susceptible to primary infection. The total number of women positive for anti-CMV IgM, and hence suspected of being infected with the virus during or shortly before their pregnancy, was 43 (0.7%). An acute infection was therefore diagnosed in 4.35% of IgG seronegative women. A significantly higher CMV seropositivity rate was found in the parturient population as compared to surveys conducted in Israel in the 1970's. The seropositivity rates found in Israel are similar to those reported in Asia and Africa. The rate of serosusceptibility and the risk of primary CMV infection in pregnancy are lower in Israel than in Europe and North America. According to the observed incidence of primary CMV infection in pregnant women, it can be estimated that approximately 280 cases of fetal infection occur in Israel every year, potentially resulting in 56 symptomatic newborns.
我们研究的目的是评估以色列孕妇群体中对巨细胞病毒（CMV）的血清学免疫力。我们采用酶免疫分析法检测了6126名孕妇的CMV IgG和IgM抗体滴度。其中，84.3%的孕妇抗CMV IgG呈阳性，15.7%血清学阴性，因此易发生原发性感染。抗CMV IgM呈阳性、因而怀疑在孕期或临产前感染该病毒的孕妇总数为43人（0.7%）。因此，在4.35%的IgG血清学阴性孕妇中诊断出急性感染。与以色列20世纪70年代开展的调查相比，产妇群体中的CMV血清阳性率显著更高。以色列的血清阳性率与亚洲和非洲报告的相似。以色列孕期血清易感性率和原发性CMV感染风险低于欧洲和北美。根据观察到的孕妇原发性CMV感染发病率，估计以色列每年约有280例胎儿感染，可能导致56例有症状的新生儿。
