5-氟尿嘧啶离子导入疗法治疗鲍恩病。
5-fluorouracil iontophoretic therapy for Bowen's disease.
作者信息
Welch M L, Grabski W J, McCollough M L, Skelton H G, Smith K J, Menon P A, Anderson L L
机构信息
Dermatology Service, Walter Reed Army Medical Center, Washington, USA.
出版信息
J Am Acad Dermatol. 1997 Jun;36(6 Pt 1):956-8. doi: 10.1016/s0190-9622(97)80280-0.
BACKGROUND
Topical 5-fluorouracil (5-FU) is an accepted therapy for Bowen's disease. Recurrences with this method have been attributed to deep follicular involvement and poor patient compliance because of the prolonged treatment time required.
OBJECTIVE
We sought to determine whether iontophoresis of 5-FU is an effective therapy for Bowen's disease.
METHODS
Twenty-six patients with biopsy-proven Bowen's disease received eight 5-FU iontophoretic treatments in 4 weeks. Local excision was done 3 months after the last treatment. The specimens were step-sectioned and evaluated for any histologic evidence of bowenoid changes.
RESULTS
Only 1 of 26 patients showed histologic evidence of Bowen's disease 3 months after treatment.
CONCLUSION
5-FU iontophoresis appears to be a safe, effective, and well-tolerated therapy for Bowen's disease.
背景
外用5-氟尿嘧啶（5-FU）是治疗鲍温病的一种公认疗法。采用这种方法出现复发的原因是毛囊深部受累以及由于所需治疗时间较长导致患者依从性差。
目的
我们试图确定5-FU离子导入疗法是否是治疗鲍温病的有效疗法。
方法
26例经活检证实为鲍温病的患者在4周内接受了8次5-FU离子导入治疗。最后一次治疗3个月后进行局部切除。对标本进行连续切片，并评估是否有任何鲍温样改变的组织学证据。
结果
26例患者中只有1例在治疗3个月后显示有鲍温病的组织学证据。
结论
5-FU离子导入疗法似乎是一种治疗鲍温病安全、有效且耐受性良好的疗法。
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