Karpiński Tomasz M
Department of Medical Microbiology, Poznań University of Medical Sciences, Wieniawskiego 3, 61-712 Poznań, Poland.
Pharmaceutics. 2018 Oct 25;10(4):204. doi: 10.3390/pharmaceutics10040204.
Iontophoresis is a non-invasive method of systemic and local drug delivery using an electric field. Iontophoresis enables diffusion of the selected drug via skin, mucosa, enamel, dentin, and other tissues. The amount of delivered therapeutic molecules is about 10⁻2000 times greater than conventional forms of delivery. Among other fields, this method is used in dentistry, ophthalmology, otorhinolaryngology, and dermatology. According to related literature, the most important drugs studied or administered by iontophoresis are: Local anesthetics, opioids, steroids, non-steroidal anti-inflammatory drugs, antibacterial drugs, antifungal drugs, antiviral drugs, anticancer drugs, fluorides, and vitamins. The present review covers current available data regarding the selected medicines used in iontophoresis. Furthermore, indications and conditions of iontophoresis application are reviewed.
离子导入法是一种利用电场进行全身和局部药物递送的非侵入性方法。离子导入法能使选定的药物通过皮肤、黏膜、牙釉质、牙本质和其他组织扩散。递送的治疗性分子数量比传统给药形式大10到2000倍左右。在其他领域中，这种方法用于牙科、眼科、耳鼻喉科和皮肤科。根据相关文献，通过离子导入法研究或给药的最重要药物有：局部麻醉药、阿片类药物、类固醇、非甾体抗炎药、抗菌药物、抗真菌药物、抗病毒药物、抗癌药物、氟化物和维生素。本综述涵盖了有关离子导入法中使用的选定药物的现有数据。此外，还对离子导入法的应用指征和条件进行了综述。
