用5-氟尿嘧啶对鲍温病进行局部治疗。
Topical treatment of Bowen's disease with 5-Fluorouracil.
作者信息
Bargman Howard, Hochman Jacqueline
机构信息
Division of Dermatology, Sunnybrook and Women's Health Sciences Centre, University of Toronto, Ontario, Canada.
出版信息
J Cutan Med Surg. 2003 Mar-Apr;7(2):101-5. doi: 10.1007/s10227-002-0158-6. Epub 2002 Nov 27.
BACKGROUND
Bowen's disease is a common skin cancer. There are many different therapeutic approaches to treatment. Topical 5-Fluorouracil (5-FU) cream has been used for many years and there are many published papers attesting to its effectiveness. However, no papers have presented long-term followup results with biopsy confirmation of cure.
OBJECTIVES
The purpose of this article is to present the long-term findings following the use of this cream in the treatment of Bowen's disease.
METHODS
Twenty-four patients with 26 biopsy-confirmed lesions of Bowen's disease were treated with topical 5-Fluorouracil cream and were followed for periods of up to 10 years. Posttreatment biopsies were performed in most cases.
RESULTS
Two of the 26 lesions treated topically recurred at some point. The rest were apparently cured.
CONCLUSION
The results presented in this article confirm that treatment of Bowen's disease with topical 5-Fluorouracil cream is safe and effective treatment.
背景
鲍恩病是一种常见的皮肤癌。治疗方法有多种。外用5-氟尿嘧啶（5-FU）乳膏已使用多年，并有许多发表的论文证明其有效性。然而，尚无论文呈现经活检证实治愈的长期随访结果。
目的
本文旨在呈现使用该乳膏治疗鲍恩病后的长期研究结果。
方法
24例经活检确诊为鲍恩病的患者，共26处病损，接受外用5-氟尿嘧啶乳膏治疗，并随访长达10年。多数病例在治疗后进行了活检。
结果
26处接受局部治疗的病损中有2处曾在某个时间点复发。其余病损明显治愈。
结论
本文所呈现的结果证实，外用5-氟尿嘧啶乳膏治疗鲍恩病是一种安全有效的治疗方法。
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