Allen R P, Wagman A M, Funderburk F R
Adv Exp Med Biol. 1977;85A:629-40. doi: 10.1007/978-1-4899-5181-6_40.
Slow wave sleep abnormalities characterize the sleep of alcoholics. In this report, two questions are addressed: (1) Does the slow wave sleep loss in alcohol withdrawal relate to withdrawal treatment? (2) Do the slow wave sleep changes on and off alcohol relate to the clinical course of alcoholism? The first question was addressed by comparing recovery in sleep EEG and clinical measures following two types of alcohol withdrawal treatment. Eighteen subjects were randomly assigned to either a low dose ethanol or chlordiazepoxide treatment for alcohol withdrawal. The results indicate that chlordiazepoxide produces a marked synergism with alcohol withdrawal suppression of slow wave sleep. The second question was addressed by an experimental alcoholization study involving 9 subjects who drank for 5 consecutive days, with 18 ounces of 95 proof ethanol consumed daily. Changes in slow wave sleep from baseline (abstinent) values to those on alcohol showed faster rate of tolerance development for the low slow wave sleep subjects. The rate of tolerance development was significantly related to treatment outcome, with faster tolerance development associated with poorer treatment outcome. In this regard it is noted that the use of chlordiazepoxide in alcohol withdrawl needs to be reviewed for potentially prolonging tolerance ""carryover" and thereby being counterproductive for treatment outcome.
慢波睡眠异常是酗酒者睡眠的特征。在本报告中，探讨了两个问题：（1）酒精戒断时的慢波睡眠缺失与戒断治疗有关吗？（2）饮酒前后慢波睡眠的变化与酒精中毒的临床病程有关吗？通过比较两种酒精戒断治疗后睡眠脑电图和临床指标的恢复情况来回答第一个问题。18名受试者被随机分配接受低剂量乙醇或氯氮卓治疗酒精戒断。结果表明，氯氮卓与酒精戒断对慢波睡眠的抑制产生显著协同作用。通过一项实验性酒精摄入研究回答第二个问题，该研究涉及9名受试者，他们连续5天饮酒，每天饮用18盎司95度的乙醇。慢波睡眠从基线（戒酒）值到饮酒时的值的变化表明，慢波睡眠低的受试者耐受性发展速度更快。耐受性发展速度与治疗结果显著相关，耐受性发展越快，治疗结果越差。在这方面，需要重新审视在酒精戒断中使用氯氮卓的情况，因为它可能会延长耐受性“残留”，从而对治疗结果产生反作用。
