Chan A W, Leong F W, Schanley D L, Howe S M
Pharmacol Biochem Behav. 1981 Aug;15(2):185-9. doi: 10.1016/0091-3057(81)90175-1.
Withdrawal reactions were compared in C57BL/6J mice, which had been fed an ethanolic liquid diet containing chloridazepoxide (CDP, 3.2 or 6.4 mg/100 ml, group B or C, respectively) with those which had been administered an ethanol diet alone (group A) for 15 days. Group A showed a significantly more pronounced decrease in rectal temperature (4 to 10 hr) and a higher withdrawal score (4 to 14 hr) than mice in groups B and C. The differences in withdrawal signs still persisted even after mice were fed an ethanol diet without CDP for one extra day before withdrawal. The presence of metabolites of CDP in the blood during withdrawal could only account for a minor contribution to the protective effect. Our data are more suggestive of an increased rate of ethanol metabolism leading to lower blood alcohol levels during diet intake period as being the major factor. However we cannot rule out the alternative possibility that CDP or its metabolites might interfere with the development of tolerance to and physical dependence on alcohol.
对C57BL/6J小鼠的戒断反应进行了比较，这些小鼠被喂食含有氯氮卓（CDP，分别为3.2或6.4毫克/100毫升，B组或C组）的乙醇液体饮食15天，与之比较的是仅给予乙醇饮食的小鼠（A组）。与B组和C组的小鼠相比，A组的直肠温度显著下降幅度更大（4至10小时），戒断评分更高（4至14小时）。即使在戒断前额外一天给小鼠喂食不含CDP的乙醇饮食后，戒断症状的差异仍然存在。戒断期间血液中CDP代谢物的存在对保护作用的贡献很小。我们的数据更表明，在饮食摄入期间乙醇代谢率增加导致血液酒精水平降低是主要因素。然而，我们不能排除CDP或其代谢物可能干扰对酒精耐受性和身体依赖性发展的另一种可能性。
