Daoud M S, Hutton K P, Gibson L E
Department of Dermatology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Br J Dermatol. 1997 May;136(5):706-13.
Cutaneous periarteritis nodosa (PAN) is a well-recognized entity characterized by tender subcutaneous nodules and livedo that may ulcerate. The pathogenesis of cutaneous PAN is not known. The objective of the study was to evaluate the clinical and histological features of 79 cases of cutaneous PAN and to investigate any clinical, pathological and immunological differences that may distinguish those cases likely to have a prolonged course. A retrospective analysis of 79 cases was conducted. Thirty-nine patients had ulcers during the course of their illness. Women were affected more than men. Painful nodules on the lower extremities, with oedema and swelling, were the most common clinical finding; 22% of patients had some evidence of neuropathy. Most of the laboratory findings were non-specific. There was no evidence for hepatitis B infection and hepatitis C infection was present in only one patient. Most patients (60%) had no associated medical condition. The disease course was prolonged but benign, and systemic PAN did not develop in any patient. Corticosteroids given systemically induced remission in most acute cases. The ulcerative form of disease was more prolonged and frequently associated with neuropathy.
皮肤结节性多动脉炎（PAN）是一种公认的疾病，其特征为压痛性皮下结节和可能发生溃疡的青斑。皮肤PAN的发病机制尚不清楚。本研究的目的是评估79例皮肤PAN的临床和组织学特征，并调查可能区分那些病程可能延长的病例的任何临床、病理和免疫学差异。对79例病例进行了回顾性分析。39例患者在病程中出现溃疡。女性受累多于男性。下肢疼痛性结节伴水肿和肿胀是最常见的临床发现；22%的患者有一些神经病变的证据。大多数实验室检查结果无特异性。没有乙型肝炎感染的证据，仅1例患者存在丙型肝炎感染。大多数患者（60%）无相关内科疾病。病程延长但为良性，无患者发展为系统性PAN。大多数急性病例全身应用糖皮质激素可诱导缓解。溃疡型疾病病程更长，且常与神经病变相关。
