Liu L, Song S, Wei W
Union Hospital of Tongji Medical University, Wuhan.
Zhonghua Fu Chan Ke Za Zhi. 1996 Jun;31(6):338-40.
To investigate the changes of urinary fibrinopeptide A (FPA) level in pregnancy induced hypertension (PIH) and its clinical significance.
High performance liquid chromatography (HPLC) was employed in determination. Urinary FPA was measured in 96 cases of normal pregnancy and 49 cases with PIH.
The urinary FPA levels in mild and moderate PIH groups were significantly higher than that in normal pregnancy (71.65 +/- 18.53 micrograms/L vs 40.17 +/- 20.26 micrograms/L, P < 0.01). The levels of urinary FPA in patients with preeclampsia increased significantly (146.65 +/- 32.53 micrograms/L) when compared with the mild and moderate PIH groups (P < 0.001). The levels of urinary FPA in patients with eclampsia (422.93 +/- 81.46 micrograms/L) were much higher than that in group of preeclampsia (P < 0.001).
It showed that the assay of urinary FPA might be helpful for earlier diagnosis, classification, treatment and judgement of prognosis in PIH.
探讨妊娠高血压综合征（PIH）患者尿纤维蛋白肽A（FPA）水平的变化及其临床意义。
采用高效液相色谱法（HPLC）进行测定。检测96例正常妊娠孕妇及49例PIH患者的尿FPA水平。
轻度和中度PIH组的尿FPA水平显著高于正常妊娠组（71.65±18.53微克/升 vs 40.17±20.26微克/升，P<0.01）。与轻度和中度PIH组相比，子痫前期患者的尿FPA水平显著升高（146.65±32.53微克/升，P<0.001）。子痫患者的尿FPA水平（422.93±81.46微克/升）远高于子痫前期组（P<0.001）。
结果表明，检测尿FPA可能有助于PIH的早期诊断、分类、治疗及预后判断。
