[Clinical significance of changes of urinary enzymes in pregnancy induced hypertension].

OBJECTIVE

To study the clinical significance of changes of N-acetyl-beta-D-glucosaminidase (NAG) and lysozyme in random urine sample in pregnancy induced hypertension (PIH).

METHODS

The concentration of NAG was measured by oronitrophenol spectrophotometric methods, and the concentration of lysozyme by agar plate diffusion method. Random urine samples from 266 pregnant women were examined, 110 cases were normal pregnant women, 156 cases were PIH patients.

RESULTS

(1) The level of NAG and lysozyme in moderate and severe PIH patients were significantly higher than that in mild PIH patients and normal pregnant women (P < 0.01) and it increased with the severity of disease. (2) There was a positive correlation between NAG and protein/creatinine (Pr/Cr) ratio in random urine. (3) There was a positive correlation between urinary lysozyme and serum beta 2-microglobulin (r = 0.874, P < 0.05).

CONCLUSION

Determination of urinary NAG and lysozyme levels will differentiate various states of PIH.