Tian G, Huang Q, Yu H
Second Affiliated Hospital of Guangzhou Medical College.
Zhonghua Fu Chan Ke Za Zhi. 1996 Aug;31(8):465-7.
To study the clinical significance of changes of N-acetyl-beta-D-glucosaminidase (NAG) and lysozyme in random urine sample in pregnancy induced hypertension (PIH).
The concentration of NAG was measured by oronitrophenol spectrophotometric methods, and the concentration of lysozyme by agar plate diffusion method. Random urine samples from 266 pregnant women were examined, 110 cases were normal pregnant women, 156 cases were PIH patients.
(1) The level of NAG and lysozyme in moderate and severe PIH patients were significantly higher than that in mild PIH patients and normal pregnant women (P < 0.01) and it increased with the severity of disease. (2) There was a positive correlation between NAG and protein/creatinine (Pr/Cr) ratio in random urine. (3) There was a positive correlation between urinary lysozyme and serum beta 2-microglobulin (r = 0.874, P < 0.05).
Determination of urinary NAG and lysozyme levels will differentiate various states of PIH.
研究妊娠高血压综合征（PIH）患者随机尿中N-乙酰-β-D-氨基葡萄糖苷酶（NAG）和溶菌酶变化的临床意义。
采用邻硝基苯酚分光光度法测定NAG浓度，琼脂平板扩散法测定溶菌酶浓度。检测266例孕妇的随机尿样，其中110例为正常孕妇，156例为PIH患者。
（1）中、重度PIH患者的NAG和溶菌酶水平显著高于轻度PIH患者和正常孕妇（P<0.01），且随病情严重程度增加。（2）随机尿中NAG与蛋白/肌酐（Pr/Cr）比值呈正相关。（3）尿溶菌酶与血清β2-微球蛋白呈正相关（r=0.874，P<0.05）。
测定尿NAG和溶菌酶水平有助于鉴别PIH的不同状态。
