Yin D, Zhang X, Feng Y
Obstetric and Gynecology Hospital, Shanghai Medical University.
Zhonghua Fu Chan Ke Za Zhi. 1996 May;31(5):291-2.
To investigate the effects of recombinant human tumor necrosis factor (rhTNF) on the growth of ascitic tumor and expression of c-erbB2 in the nude mouse models of ovarian cancer.
By intraabdominal injection, rhTNF was delivered to the peritoneal cavity of nude mouse with ovarian cancer as well as control group, after 6 days treatment, tumor cell counting and expression of c-erbB2 were detected by indirect fluorescence flow cytometry.
There is a significant difference in tumor cell counting between the study group and control group (P < 0.01). Expression of c-erbB2 in study group was lower than that in control group.
rhTNF was demonstrated to have effects on both inhibition of ascitis tumor development and down regulation of c-erbB2 expression in nude mouse with ovarian cancer.
探讨重组人肿瘤坏死因子（rhTNF）对卵巢癌裸鼠模型腹水肿瘤生长及c-erbB2表达的影响。
通过腹腔注射，将rhTNF注入患有卵巢癌的裸鼠腹腔以及对照组，治疗6天后，采用间接荧光流式细胞术检测肿瘤细胞计数及c-erbB2的表达。
研究组与对照组在肿瘤细胞计数上存在显著差异（P<0.01）。研究组中c-erbB2的表达低于对照组。
已证明rhTNF对抑制卵巢癌裸鼠腹水肿瘤发展及下调c-erbB2表达均有作用。
