[泪腺多形性腺瘤中细胞DNA与表皮生长因子受体表达的关系]
[Relationship between cellular DNA and expression of epidermal growth factor receptor in pleomorphic adenoma of lacrimal gland].
作者信息
Zheng L, He S, Fan Z
机构信息
Ophthalmology Department, First Affiliated Hospital, Second Military Medical University, Shanghai.
出版信息
Zhonghua Yan Ke Za Zhi. 1996 Mar;32(2):133-5.
OBJECTIVE
To obtain the information about whether expression of epidermal growth factor (EGF) receptor is related to the proliferative activity of tumor.
METHODS
The expression of EGF receptor and DNA content of pleomorphic adenoma of lacrimal gland in 32 cases were detected by an immunohistochemical avidin biotin peroxidase complex method and determined by an image analysis technique, respectively. The relationship between the expression of EGF receptor and DNA content was analyzed.
RESULTS
10 tumors were stained positively with anti-EGF receptor antibody, the DNA contents of 14 cases were increased, their DNA ploidy distribution pattern showed two or several peaks. Good correlation has been found between the expression of EGF receptor and DNA ploidy distribution pattern, and the DNA distribution pattern of tumor with positive EGF receptor expression showed mainly two or several peaks (P < 0.01).
CONCLUSION
The expression of EGF receptor of pleomorphic tumor of lacrimal gland is related to the proliferative activity of tumor cells.
目的
获取表皮生长因子（EGF）受体的表达是否与肿瘤增殖活性相关的信息。
方法
采用免疫组织化学抗生物素蛋白 - 生物素过氧化物酶复合物法检测32例泪腺多形性腺瘤中EGF受体的表达，并分别用图像分析技术测定DNA含量。分析EGF受体表达与DNA含量之间的关系。
结果
10例肿瘤抗EGF受体抗体染色呈阳性，14例DNA含量增加，其DNA倍体分布模式显示两个或几个峰。EGF受体表达与DNA倍体分布模式之间存在良好相关性，EGF受体表达阳性的肿瘤DNA分布模式主要显示两个或几个峰（P < 0.01）。
结论
泪腺多形性肿瘤中EGF受体的表达与肿瘤细胞的增殖活性相关。
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