Legon'kova L F, Bushma M I, Zverinskiĭ I V, Abakumov G Z, Zavodnik L V
Eksp Klin Farmakol. 1997 Mar-Apr;60(2):68-71.
Four days after a single intragastric injection of CCl4 (5 mg/kg as a 50% oil solution) increased intensity of a chemoluminescence "quick flush" in the hepatic microsomes and blood serum, as well as hepatocyte cytolysis (increased ALT activity) and decreased rate of antipyrine elimination from the blood were recorded in rats. The content of cytochromes P-450 and b5 activity of NADH-cytochrome b5 reductase and cytosol glutathione transferase in the hepatic microsomal fractions reduced in this case. Administration of methionine (200 mg/kg) and its combination with nicotinamide (60 mg/kg) without and, particularly, with additional prescription of vitamin E (150 mg/kg) produced a marked antioxidant and enzyme-normalizing effects in the rats.
大鼠单次胃内注射四氯化碳（50%油溶液，5mg/kg）4天后，肝微粒体和血清中化学发光“快速冲洗”强度增加，同时记录到肝细胞溶解（谷丙转氨酶活性增加）以及血液中安替比林消除率降低。在此情况下，肝微粒体部分细胞色素P - 450含量、NADH - 细胞色素b5还原酶和胞质谷胱甘肽转移酶的b5活性降低。给予蛋氨酸（200mg/kg）及其与烟酰胺（60mg/kg）的组合，尤其在额外给予维生素E（150mg/kg）时，对大鼠产生了显著的抗氧化和酶活性正常化作用。
