Zubzhitskaia L B, Aĭlamazian E K, Parusov V N, Kosheleva N G, Semenov V V, Mikhnina E A
Arkh Patol. 1997 Mar-Apr;59(2):17-22.
Peculiar ultrastructural features allowed the authors to reveal M. Homminis corpuscles in placental tissues of women with genital mycoplasmosis. Mycoplasma was found in the amniotic epithelium, chorionic plate, in the lumen of villous capillaries, this showing possible hematogenic way of the infection from mother to fetus. In the placenta of women with genital mycoplasmosis immunopathological processes develop in association with formation of pathogenic immune complexes (PIC) that are fixing the C3 complement fraction. Location of PIC on the syncytiotrophoblast membranes and vascular endothelium causes immunological inflammation with the involvement of immunocompetent cells resulting in the destruction of syncytial membranes and membranes of the placental barrier. Damage to the placental barrier membranes promotes the development of placental failure, a complicated course of pregnancy and delivery, deterioration of the state of the fetus and newborn infant.
独特的超微结构特征使作者能够在患有生殖支原体病的女性胎盘组织中发现霍氏支原体小体。在羊膜上皮、绒毛膜板、绒毛毛细血管腔内发现了支原体，这表明感染可能通过血源性途径从母亲传播给胎儿。在患有生殖支原体病的女性胎盘中，免疫病理过程与致病性免疫复合物（PIC）的形成相关，这些复合物会固定C3补体成分。PIC位于合体滋养层细胞膜和血管内皮上，会引发免疫炎症，免疫活性细胞参与其中，导致合体细胞膜和胎盘屏障膜的破坏。胎盘屏障膜的损伤会促进胎盘功能不全、妊娠和分娩过程复杂化、胎儿和新生儿状态恶化的发展。
