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Processing of Alzheimer's amyloid precursor protein during H2O2-induced apoptosis in human neuronal cells.

作者信息

Zhang L, Zhao B, Yew D T, Kusiak J W, Roth G S

机构信息

Laboratory of Cellular and Molecular Biology, Gerontology Research Center, NIA/NIH, Baltimore, Maryland, USA.

出版信息

Biochem Biophys Res Commun. 1997 Jun 27;235(3):845-8. doi: 10.1006/bbrc.1997.6698.

DOI:10.1006/bbrc.1997.6698
PMID:9207249
Abstract

The processing of Alzheimer's amyloid precursor protein was studied by Western blotting during H2O2 induced apoptosis in cultures of human neuroblastoma cells. A new 5.5 kDa fragment putatively containing intact A beta was detected and found to be highly associated with apoptosis. The results suggest a possible vicious cycle involving H2O2, A beta and apoptosis which may contribute to the neuronal death mechanism in Alzheimer's Disease.

摘要

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