Schvarcz E, Palmér M, Aman J, Horowitz M, Stridsberg M, Berne C
Department of Internal Medicine, Orebro Medical Center Hospital, Sweden.
Gastroenterology. 1997 Jul;113(1):60-6. doi: 10.1016/s0016-5085(97)70080-5.
BACKGROUND & AIMS: Marked hyperglycemia slows and hypoglycemia accelerates gastric emptying. The aim of this study was to determine the effect of physiological changes in blood glucose gastric emptying.
In 8 healthy subjects and 9 patients with insulin-dependent diabetes mellitus (IDDM) without gastrointestinal tract symptoms or evidence of neuropathy, gastric emptying of a mixed meal was measured by scintigraphy. Using an insulin-glucose clamp, the blood glucose concentration was stabilized at 4 and 8 mmol/L on 2 separate days.
The intragastric retention of the solid meal component at 100 minutes was 55.2% +/- 4.5% at 8 mmol/L vs. 36.7% +/- 5.5% at 4 mmol/L (P = 0.004) in normal subjects and 44.2% +/- 4.2% vs. 35.7% +/- 4.2% (P = 0.004) in patients with IDDM. The time taken for 50% emptying of the liquid meal was 57.0 +/- 10.8 minutes at 8 mmol/L vs. 32.2 +/- 12.6 minutes at 4 mmol/L (P = 0.002) in normal subjects and 41.3 +/- 3.4 minutes vs. 29.1 +/- 3.5 minutes (P = 0.002) in patients with IDDM.
Changes in blood glucose within the normal postprandial range have a significant impact on gastric emptying in both normal subjects and patients with IDDM.
显著高血糖会减缓胃排空，而低血糖则会加速胃排空。本研究旨在确定血糖生理变化对胃排空的影响。
对8名健康受试者和9名无胃肠道症状或神经病变证据的胰岛素依赖型糖尿病（IDDM）患者，通过闪烁扫描法测量混合餐的胃排空情况。使用胰岛素-葡萄糖钳夹技术，在2个不同日期将血糖浓度稳定在4和8 mmol/L。
正常受试者中，固体餐成分在100分钟时的胃内潴留率在8 mmol/L时为55.2%±4.5%，在4 mmol/L时为36.7%±5.5%（P = 0.004）；IDDM患者中，该潴留率分别为44.2%±4.2%和35.7%±4.2%（P = 0.004）。正常受试者中，液体餐50%排空所需时间在8 mmol/L时为57.0±10.8分钟，在4 mmol/L时为32.2±12.6分钟（P = 0.002）；IDDM患者中，该时间分别为41.3±3.4分钟和29.1±3.5分钟（P = 0.002）。
正常餐后范围内的血糖变化对正常受试者和IDDM患者的胃排空均有显著影响。
