生理性高血糖会减缓正常受试者和胰岛素依赖型糖尿病患者的胃排空。

Physiological hyperglycemia slows gastric emptying in normal subjects and patients with insulin-dependent diabetes mellitus.

作者信息

Schvarcz E, Palmér M, Aman J, Horowitz M, Stridsberg M, Berne C

机构信息

Department of Internal Medicine, Orebro Medical Center Hospital, Sweden.

出版信息

Gastroenterology. 1997 Jul;113(1):60-6. doi: 10.1016/s0016-5085(97)70080-5.

DOI:10.1016/s0016-5085(97)70080-5

PMID:9207262

Abstract

BACKGROUND & AIMS: Marked hyperglycemia slows and hypoglycemia accelerates gastric emptying. The aim of this study was to determine the effect of physiological changes in blood glucose gastric emptying.

METHODS

In 8 healthy subjects and 9 patients with insulin-dependent diabetes mellitus (IDDM) without gastrointestinal tract symptoms or evidence of neuropathy, gastric emptying of a mixed meal was measured by scintigraphy. Using an insulin-glucose clamp, the blood glucose concentration was stabilized at 4 and 8 mmol/L on 2 separate days.

RESULTS

The intragastric retention of the solid meal component at 100 minutes was 55.2% +/- 4.5% at 8 mmol/L vs. 36.7% +/- 5.5% at 4 mmol/L (P = 0.004) in normal subjects and 44.2% +/- 4.2% vs. 35.7% +/- 4.2% (P = 0.004) in patients with IDDM. The time taken for 50% emptying of the liquid meal was 57.0 +/- 10.8 minutes at 8 mmol/L vs. 32.2 +/- 12.6 minutes at 4 mmol/L (P = 0.002) in normal subjects and 41.3 +/- 3.4 minutes vs. 29.1 +/- 3.5 minutes (P = 0.002) in patients with IDDM.

CONCLUSIONS

Changes in blood glucose within the normal postprandial range have a significant impact on gastric emptying in both normal subjects and patients with IDDM.

摘要

背景与目的

显著高血糖会减缓胃排空，而低血糖则会加速胃排空。本研究旨在确定血糖生理变化对胃排空的影响。

方法

对8名健康受试者和9名无胃肠道症状或神经病变证据的胰岛素依赖型糖尿病（IDDM）患者，通过闪烁扫描法测量混合餐的胃排空情况。使用胰岛素-葡萄糖钳夹技术，在2个不同日期将血糖浓度稳定在4和8 mmol/L。

结果

正常受试者中，固体餐成分在100分钟时的胃内潴留率在8 mmol/L时为55.2%±4.5%，在4 mmol/L时为36.7%±5.5%（P = 0.004）；IDDM患者中，该潴留率分别为44.2%±4.2%和35.7%±4.2%（P = 0.004）。正常受试者中，液体餐50%排空所需时间在8 mmol/L时为57.0±10.8分钟，在4 mmol/L时为32.2±12.6分钟（P = 0.002）；IDDM患者中，该时间分别为41.3±3.4分钟和29.1±3.5分钟（P = 0.002）。