Fraser R J, Horowitz M, Maddox A F, Harding P E, Chatterton B E, Dent J
Department of Medicine, Royal Adelaide Hospital, North Terrace, Australia.
Diabetologia. 1990 Nov;33(11):675-80. doi: 10.1007/BF00400569.
In 10 patients with Type 1 (insulin-dependent) diabetes mellitus gastric emptying of a digestible solid and liquid meal was measured during euglycaemia (blood glucose concentration 4-8 mmol/l) and during hyperglycaemia (blood glucose concentration 16-20 mmol/l). Gastric emptying was studied with a scintigraphic technique and blood glucose concentrations were stabilised using a modified glucose clamp. Patients were also evaluated for gastrointestinal symptoms, autonomic nerve function and glycaemic control. When compared to euglycaemia, the duration of the lag phase before any of the solid meal emptied from the stomach (p = 0.032), the percentage of the solid meal remaining in the stomach at 100 min (p = 0.032) and the 50% emptying time for the solid meal (p = 0.032) increased during hyperglycaemia. The 50% emptying time for the liquid meal (p = 0.042) was also prolonged during the period of hyperglycaemia. These results demonstrate that the rate of gastric emptying in Type 1 diabetes is affected by the blood glucose concentration.
在10例1型（胰岛素依赖型）糖尿病患者中，采用闪烁扫描技术，在血糖正常（血糖浓度4 - 8 mmol/L）和高血糖（血糖浓度16 - 20 mmol/L）状态下，测定了可消化固体和液体餐的胃排空情况。使用改良的葡萄糖钳夹法稳定血糖浓度。还对患者的胃肠道症状、自主神经功能和血糖控制情况进行了评估。与血糖正常相比，在高血糖期间，固体餐从胃中排空前的延迟期持续时间（p = 0.032）、100分钟时胃内剩余固体餐的百分比（p = 0.032）以及固体餐的50%排空时间（p = 0.032）均增加。在高血糖期间，液体餐的50%排空时间（p = 0.042）也延长。这些结果表明，1型糖尿病患者的胃排空速率受血糖浓度影响。
