慢性活动性EB病毒感染中的病毒白细胞介素-10

Viral interleukin-10 in chronic active Epstein-Barr virus infection.

作者信息

Kanegane H, Wakiguchi H, Kanegane C, Kurashige T, Tosato G

机构信息

Division of Hematologic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA.

出版信息

J Infect Dis. 1997 Jul;176(1):254-7. doi: 10.1086/517260.

DOI:10.1086/517260

PMID:9207376

Abstract

Viral interleukin-10 (IL-10), a product of the Epstein-Barr virus (EBV) replication gene BCRF1, shares extensive structural and functional similarity with the human cytokine IL-10. Both viral and human IL-10 inhibit T cell growth and interferon-gamma production. With two ELISAs, one that recognized both human and viral (total) IL-10 and the other specific for viral IL-10, IL-10 was measured in serum or plasma from 34 patients with chronic active EBV infection (CAEBV) and from 15 healthy controls. Of the patients, 56% had measurable total IL-10 and 29% had measurable viral IL-10. In contrast, total IL-10 was detectable in only 2 of 15 controls and viral IL-10 was undetectable. Thus, many patients with CAEBV have abnormally high levels of circulating IL-10 that may contribute to disease pathogenesis by inhibiting host immunity.

摘要

病毒白细胞介素-10（IL-10）是爱泼斯坦-巴尔病毒（EBV）复制基因BCRF1的产物，与人类细胞因子IL-10在结构和功能上有广泛的相似性。病毒IL-10和人类IL-10都能抑制T细胞生长和γ干扰素的产生。使用两种酶联免疫吸附测定法（ELISA），一种可识别人类和病毒（总）IL-10，另一种对病毒IL-10具有特异性，对34例慢性活动性EBV感染（CAEBV）患者和15名健康对照者的血清或血浆中的IL-10进行了检测。在这些患者中，56%的患者可检测到总IL-10，29%的患者可检测到病毒IL-10。相比之下，15名对照者中只有2人可检测到总IL-10，未检测到病毒IL-10。因此，许多CAEBV患者循环中的IL-10水平异常升高，可能通过抑制宿主免疫而导致疾病发病机制。