Aker J S, Mancoll J, Lewis B, Colen L B
Division of Plastic and Reconstructive Surgery, Pennsylvania State University, Hershey, USA.
Plast Reconstr Surg. 1997 Jul;100(1):66-71. doi: 10.1097/00006534-199707000-00011.
Cigarette smoke, and specifically nicotine, has been shown to reduce skin-flap survival. The purpose of this study was to determine if the preoperative administration of pentoxifylline can counteract the deleterious effects of nicotine on skin-flap survival in the rat. Sixty rats were distributed into four groups (n = 15). The survival of modified McFarlane skin flaps was assessed on postoperative day 7. The administration of nicotine (0.6 mg/kg) for 24 weeks preoperatively produced an average skin-flap survival of 59 percent; this was significantly decreased compared with controls (p < 0.05). When similarly treated animals were given pentoxifylline (20 mg/kg) for 30 days preoperatively, the mean skin-flap survival improved significantly to 80 percent (p < 0.05). Withholding nicotine for 2 weeks preoperatively also was found to significantly improve skin-flap survival to 73 percent (p < 0.05). Blood filterability was measured as an indicator of viscosity. The blood filterability in rats that received nicotine for 24 weeks was significantly decreased compared with controls (p < 0.05). Both the addition of pentoxifylline preoperatively and the withholding of nicotine for 2 weeks preoperatively were found to significantly improve blood filterability compared with rats that received nicotine alone for 24 weeks postoperatively (p < 0.05).
业已表明，香烟烟雾，尤其是尼古丁，会降低皮瓣存活率。本研究的目的是确定术前给予己酮可可碱是否能够抵消尼古丁对大鼠皮瓣存活的有害影响。60只大鼠被分为四组（每组n = 15）。在术后第7天评估改良麦克法兰皮瓣的存活率。术前给予尼古丁（0.6毫克/千克）24周，皮瓣平均存活率为59%；与对照组相比显著降低（p < 0.05）。当对同样接受治疗的动物术前给予己酮可可碱（20毫克/千克）30天时，皮瓣平均存活率显著提高至80%（p < 0.05）。还发现术前2周不给予尼古丁也可使皮瓣存活率显著提高至73%（p < 0.05）。测量血液过滤性作为黏度指标。接受尼古丁24周的大鼠的血液过滤性与对照组相比显著降低（p < 0.05）。与术后单独接受尼古丁24周的大鼠相比，术前给予己酮可可碱以及术前2周不给予尼古丁均显著改善了血液过滤性（p < 0.05）。
