Robinson L R, Kraft G H, Fitts S S, Schneider V
Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle, USA.
Am J Phys Med Rehabil. 1997 May-Jun;76(3):191-6. doi: 10.1097/00002060-199705000-00005.
We tested the hypothesis that reducing core body temperature in subjects with multiple sclerosis (MS) improves the cortical somatosensory evoked potential (SEP) response. Twenty subjects with definite MS were compared with 20 subjects without neurologic symptoms or disease. SEPs were recorded with stimulation of the tibial and median nerves unilaterally at 3.1 and 6.1 Hz. The procedure was repeated after a cooking vest and hat reduced core body temperature by an average of 0.46 +/- 0.28 degrees C. No appreciable change in latency or amplitude of the SEP responses occurred in either the control or MS group with cooling. Although the amplitude of the cortical SEP response was less at the 6.1 Hz rate than at 3.1 Hz, there were no statistically significant differences between the MS and control groups or between stimulation rates with cooling. We conclude that, although some reports suggest symptomatic improvements during cooling in subjects with MS, this improvement may not be associated with changes in the SEP.
降低多发性硬化症（MS）患者的核心体温可改善皮质体感诱发电位（SEP）反应。将20例确诊为MS的患者与20例无神经症状或疾病的受试者进行比较。通过单侧刺激胫神经和正中神经，以3.1赫兹和6.1赫兹的频率记录SEP。在穿着加热背心和帽子使核心体温平均降低0.46±0.28摄氏度后，重复该过程。在对照组或MS组中，冷却后SEP反应的潜伏期或波幅均未出现明显变化。尽管在6.1赫兹频率下皮质SEP反应的波幅低于3.1赫兹时，但MS组与对照组之间或冷却时不同刺激频率之间均无统计学显著差异。我们得出结论，尽管一些报告表明MS患者在冷却过程中有症状改善，但这种改善可能与SEP的变化无关。
