Smith P F, Grabau J C, Werzberger A, Gunn R A, Rolka H R, Kondracki S F, Gallo R J, Morse D L
Division of Epidemiology, New York State Department of Health, Albany, USA.
Epidemiol Infect. 1997 Jun;118(3):243-52. doi: 10.1017/s0950268897007462.
An Hasidic Jewish community has experienced recurrent hepatitis A outbreaks since 1980. To assess risk factors for illness during a 1985-6 outbreak, the authors reviewed case records and randomly selected 93 households for an interview and serologic survey. In the outbreak, 117 cases of hepatitis A were identified, with the highest attack rate (4.2%) among 3-5 year olds. Among the survey households, the presence of 3-5 year olds was the only risk factor that increased a household's risk of hepatitis A (indeterminant relative risk, P = 0.02). Furthermore, case households from the outbreak were more likely to have 3-5 years olds than were control households from the survey (odds ratio = 16.4, P < 0.001). Children 3-5 years old were more likely to have hepatitis A and may have been the most frequent transmitters of hepatitis A in this community. Hepatitis A vaccination of 3-5 year olds can protect this age group and might prevent future outbreaks in the community.
自1980年以来，一个哈西德派犹太社区多次爆发甲型肝炎疫情。为评估1985 - 1986年疫情期间发病的危险因素，作者查阅了病例记录，并随机选择了93户家庭进行访谈和血清学调查。在此次疫情中，共确诊117例甲型肝炎病例，其中3至5岁儿童的发病率最高（4.2%）。在接受调查的家庭中，家中有3至5岁儿童是增加家庭感染甲型肝炎风险的唯一危险因素（相对危险度不确定，P = 0.02）。此外，疫情中的病例家庭比调查中的对照家庭更有可能有3至5岁的儿童（优势比 = 16.4，P < 0.001）。3至5岁的儿童更容易感染甲型肝炎，可能是该社区甲型肝炎最常见的传播者。对3至5岁儿童进行甲型肝炎疫苗接种可以保护这个年龄组，并可能预防该社区未来的疫情爆发。
