拉夫在生死抉择中显露出来。 - Suppr

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Raf revealed in life-or-death decisions.

作者信息

Pritchard C, McMahon M

出版信息

Nat Genet. 1997 Jul;16(3):214-5. doi: 10.1038/ng0797-214.

DOI:10.1038/ng0797-214

PMID:9207779

Abstract

摘要

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Raf revealed in life-or-death decisions.拉夫在生死抉择中显露出来。

Nat Genet. 1997 Jul;16(3):214-5. doi: 10.1038/ng0797-214.

Bcl-2 targets the protein kinase Raf-1 to mitochondria.Bcl-2将蛋白激酶Raf-1靶向定位于线粒体。

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Hypoxic activation of nuclear factor-kappa B is mediated by a Ras and Raf signaling pathway and does not involve MAP kinase (ERK1 or ERK2).核因子-κB的缺氧激活由Ras和Raf信号通路介导，且不涉及丝裂原活化蛋白激酶（ERK1或ERK2）。

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Mitogen-activated protein kinase pathways.丝裂原活化蛋白激酶信号通路

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Signalling from TPA to MAP kinase requires protein kinase C, raf and MEK: reconstitution of the signalling pathway in vitro.从佛波酯到丝裂原活化蛋白激酶的信号传导需要蛋白激酶C、raf和MEK：体外信号通路的重建。

Oncogene. 1994 Nov;9(11):3213-8.

Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase.新型丝裂原活化蛋白激酶激酶激酶Tpl-2原癌蛋白对MEK-1和SEK-1的激活作用。

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Identification of signalling proteins interacting with B-Raf in the yeast two-hybrid system.在酵母双杂交系统中鉴定与B-Raf相互作用的信号蛋白。

Oncogene. 1996 May 16;12(10):2213-21.

Comparative effects of insulin on the activation of the Raf/Mos-dependent MAP kinase cascade in vitellogenic versus postvitellogenic Xenopus oocytes.胰岛素对卵黄发生期与卵黄发生后期非洲爪蟾卵母细胞中Raf/Mos依赖性丝裂原活化蛋白激酶级联反应激活的比较效应。

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Fas-signaling and effects on receptor tyrosine kinase signal transduction in human breast epithelial cells.Fas信号传导及其对人乳腺上皮细胞中受体酪氨酸激酶信号转导的影响。

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MAP kinase cascade, but not ERKs, activated during early cleavage of mouse embryos.丝裂原活化蛋白激酶级联反应，而非细胞外信号调节激酶，在小鼠胚胎早期卵裂过程中被激活。

Mol Reprod Dev. 1998 Oct;51(2):148-55. doi: 10.1002/(SICI)1098-2795(199810)51:2<148::AID-MRD4>3.0.CO;2-Q.

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Oncogene. 2017 Apr 6;36(14):2014-2022. doi: 10.1038/onc.2016.384. Epub 2016 Nov 14.

MicroRNA and signaling pathways in gastric cancer.胃癌中的微小RNA与信号通路

Cancer Gene Ther. 2014 Aug;21(8):305-16. doi: 10.1038/cgt.2014.37. Epub 2014 Jul 25.

Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing extracellular signal-regulated kinase activation after transient focal cerebral ischemia in mice.铜锌超氧化物歧化酶通过防止小鼠短暂性局灶性脑缺血后细胞外信号调节激酶激活来减轻神经元细胞死亡。

J Neurosci. 2002 Sep 15;22(18):7923-30. doi: 10.1523/JNEUROSCI.22-18-07923.2002.

MEK kinase activity is not necessary for Raf-1 function.MEK激酶活性对于Raf-1功能并非必需。

EMBO J. 2001 Apr 17;20(8):1940-51. doi: 10.1093/emboj/20.8.1940.

Brain-derived neurotrophic factor-mediated neuroprotection of adult rat retinal ganglion cells in vivo does not exclusively depend on phosphatidyl-inositol-3'-kinase/protein kinase B signaling.脑源性神经营养因子介导的成年大鼠视网膜神经节细胞体内神经保护作用并不完全依赖磷脂酰肌醇-3'-激酶/蛋白激酶B信号通路。

J Neurosci. 2000 Sep 15;20(18):6962-7. doi: 10.1523/JNEUROSCI.20-18-06962.2000.

c-Raf regulates cell survival and retinal ganglion cell morphogenesis during neurogenesis.c-Raf在神经发生过程中调节细胞存活和视网膜神经节细胞形态发生。

J Neurosci. 2000 May 1;20(9):3254-62. doi: 10.1523/JNEUROSCI.20-09-03254.2000.

Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro.环磷酸腺苷（cAMP）水平升高足以在体外促进脊髓运动神经元的存活。

J Neurosci. 1998 Sep 15;18(18):7361-71. doi: 10.1523/JNEUROSCI.18-18-07361.1998.

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