Jackson T E, Guyton A C, Hall J E
Am J Physiol. 1977 Nov;233(5):F396-402. doi: 10.1152/ajprenal.1977.233.5.F396.
Measurement of rapid renal hemodynamic changes were made for 90 s in pentobarbital-anesthetized dogs following step increases and decreases in renal arterial pressure between 80 and 120 mm Hg. Transient analysis was used to observe time characteristics of the autoregulatory relationships which are obscured in steadystate measurements. Temporal decoupling of blood flow and glomerular filtration rate (GFR) occurred with both step increases and decreases of arterial pressure. Steady-state autoregulation of blood flow was attained in about 30 s, whereas steady-state autoregulation of GFR was not demonstrably attained even 90 s after the arterial pressure maneuver. The temporal decoupling of renal blood flow and GRR supports the concept of transient involvement of proximal tubular dynamics and efferent resistance changes during acute autoregulation of GFR following step changes in arterial pressure.
在戊巴比妥麻醉的犬中，在肾动脉压在80至120 mmHg之间进行阶跃升高和降低后，对快速肾血流动力学变化进行了90秒的测量。采用瞬态分析来观察自动调节关系的时间特征，这些特征在稳态测量中被掩盖。随着动脉压的阶跃升高和降低，血流和肾小球滤过率（GFR）出现了时间解耦。血流的稳态自动调节在大约30秒内实现，而即使在动脉压操作后90秒，GFR的稳态自动调节也未明显实现。肾血流和GRR的时间解耦支持了在动脉压阶跃变化后GFR急性自动调节过程中近端肾小管动力学和出球阻力变化短暂参与的概念。
