Kremser P C, Gewertz B L
Am J Physiol. 1985 Sep;249(3 Pt 2):F356-60. doi: 10.1152/ajprenal.1985.249.3.F356.
Renal blood flow and hemodynamic autoregulation were assessed in seven chronically instrumented canines studied in the conscious state and after pentobarbital anesthesia administration (30 mg/kg). The effects of acute arterial hemorrhage (10 and 15 ml/kg) were also studied. In the conscious state, no significant changes in autoregulation were observed following 10 mg/kg hemorrhage. With pentobarbital and 10 ml/kg hemorrhage, a significant change in the limits of autoregulation was noted (autoregulatory limit 78.5 +/- 16.6 vs. 88.4 +/- 25.3 mmHg, P less than 0.05). Four animals were also studied in the conscious state following 15 ml/kg acute arterial hemorrhage. In these animals, mean arterial pressure decreased (from 105.0 +/- 11.4 to 87.8 +/- 7.2 mmHg, P less than 0.025) but renal blood flow (from 293 +/- 38 to 272 +/- 65 ml/min) and autoregulatory limit did not change. We conclude that renal blood flow is unaffected by hemorrhage or pentobarbital alone. In the conscious state, renal pressure-flow autoregulation is maintained despite moderate hemorrhage and systemic hypotension. The lower limit of autoregulation is significantly changed by even minor hemorrhage in the pentobarbital-anesthetized state.
对7只长期植入仪器的犬进行了研究，评估其在清醒状态下以及给予戊巴比妥麻醉（30mg/kg）后的肾血流量和血流动力学自动调节功能。还研究了急性动脉出血（10和15ml/kg）的影响。在清醒状态下，10mg/kg出血后未观察到自动调节功能有显著变化。在戊巴比妥麻醉且10ml/kg出血的情况下，自动调节范围出现了显著变化（自动调节范围为78.5±16.6 vs. 88.4±25.3mmHg，P<0.05）。对4只犬在清醒状态下进行了15ml/kg急性动脉出血后的研究。在这些犬中，平均动脉压下降（从105.0±11.4降至87.8±7.2mmHg，P<0.025），但肾血流量（从293±38降至272±65ml/min）和自动调节范围未发生变化。我们得出结论，肾血流量不受单纯出血或戊巴比妥的影响。在清醒状态下，尽管出现中度出血和全身性低血压，肾压力-流量自动调节功能仍得以维持。在戊巴比妥麻醉状态下，即使是轻微出血也会使自动调节的下限发生显著变化。
