CD34 选择的自体外周血干细胞移植（PBSCT）后发生的隐孢子虫病。采用巴龙霉素、阿奇霉素和重组人白细胞介素-2 进行治疗。
Cryptosporidiosis after CD34-selected autologous peripheral blood stem cell transplantation (PBSCT). Treatment with paromomycin, azithromycin and recombinant human interleukin-2.
作者信息
Nachbaur D, Kropshofer G, Feichtinger H, Allerberger F, Niederwieser D
机构信息
Department Internal Medicine, University Hospital, Innsbruck, Austria.
出版信息
Bone Marrow Transplant. 1997 Jun;19(12):1261-3. doi: 10.1038/sj.bmt.1700826.
We report two cases of cryptosporidiosis after CD34-selected PBSCT for lymphoma. While the first patient died of pulmonary cryptosporidiosis, treatment with paromomycin, azithromycin and subcutaneous low-dose rhIL-2 to improve numerical and functional T lymphocyte defects completely eliminated infection in the second patient. We conclude, that the removal of mature T lymphocytes by positive selection of CD34+ cells bears the risk of a delayed immune reconstitution resulting in an increased incidence of severe and sometimes fatal opportunistic infections. IL-2 might be useful in this situation by accelerating immune reconstitution and reducing the danger of opportunistic infections.
我们报告了两例淋巴瘤患者在接受CD34选择的外周血干细胞移植（PBSCT）后发生隐孢子虫病的病例。首例患者死于肺隐孢子虫病，而第二例患者接受了巴龙霉素、阿奇霉素和皮下低剂量重组人白细胞介素-2（rhIL-2）治疗以改善T淋巴细胞数量和功能缺陷，感染被完全清除。我们得出结论，通过对CD34+细胞进行阳性选择去除成熟T淋巴细胞存在免疫重建延迟的风险，这会导致严重且有时致命的机会性感染发生率增加。在这种情况下，白细胞介素-2可能通过加速免疫重建和降低机会性感染的风险而发挥作用。
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