Lloyd T C, Fried J J
Am J Physiol. 1977 Nov;233(5):H587-91. doi: 10.1152/ajpheart.1977.233.5.H587.
A step increase of left atrial and pulmonary venous pressure from 0 to 25 mmHg was used in anesthetized dogs with controlled arterial blood pressure to generate reflex systemic vasodilation. The resultant response of total peripheral resistance was an initial transient fall of about 40% which spontaneously regressed while the stimulus was maintained. Injections of differently tagged radioactive microspheres were used to measure selected organ blood flows prior to raising atrial pressure, at the response peak, during the steady state, and after recovery. Resistances of skin, skeletal muscle, kidney, and large intestine significantly fell upon atriovenous distention. The response in muscle, which greatly exceeded that of the other organs, was not sustained, whereas resistances of other responding beds remained depressed until the stimulus was removed. No significant responses occurred in small intestine, liver (hepatic artery), or adrenal gland.
在动脉血压得到控制的麻醉犬中，将左心房和肺静脉压力从0 mmHg逐步升至25 mmHg，以引发反射性全身血管舒张。总外周阻力的相应反应是最初出现约40%的短暂下降，在刺激持续期间会自发恢复。在升高心房压力之前、反应峰值时、稳态期间以及恢复后，注射不同标记的放射性微球来测量选定器官的血流量。心房-静脉扩张时，皮肤、骨骼肌、肾脏和大肠的阻力显著下降。肌肉的反应大大超过其他器官，但并不持续，而其他有反应的血管床的阻力在刺激消除前一直处于降低状态。小肠、肝脏（肝动脉）或肾上腺未出现明显反应。
