Masterman D L, Cummings J L
Department of Neurology, UCLA School of Medicine, USA.
J Psychopharmacol. 1997;11(2):107-14. doi: 10.1177/026988119701100203.
A series of discrete, parallel frontal-subcortical circuits have been demonstrated to link specific areas of the frontal lobe to areas within the basal ganglia and thalamus. A variety of circuit-specific behaviors can be described involving the dorsolateral prefrontal, orbitofrontal and anterior cingulate circuits. Interruptions or imbalance occurring at various levels within these closed looped circuits is felt to underlie the characteristic behavioral patterns seen. The intricate neurochemical arrangement of the striatum and the complex neurotransmitter interactions that occur within these key subcortical structures from the basis for modulatory influences that can affect these circuits.
一系列离散的、平行的额叶-皮质下回路已被证明可将额叶的特定区域与基底神经节和丘脑内的区域相连。可以描述各种特定于回路的行为，涉及背外侧前额叶、眶额叶和前扣带回回路。这些闭环回路内各个层面出现的中断或失衡被认为是所观察到的特征性行为模式的基础。纹状体复杂的神经化学排列以及这些关键皮质下结构内发生的复杂神经递质相互作用构成了能够影响这些回路的调节性影响的基础。
