Knable M B, Weinberger D R
National Institute of Mental Health, Intramural Research Program, Clinical Brain Disorders Branch, Washington, DC 20032, USA.
J Psychopharmacol. 1997;11(2):123-31. doi: 10.1177/026988119701100205.
Dysfunction of the prefrontal cortex (PFC) in schizophrenia has been suspected based on observations from clinical, neuropsychological and neuroimaging studies. Since the PFC receives a dense dopaminergic innervation, abnormalities of the mesocortical dopamine system have been proposed to contribute to the pathophysiology of schizophrenia. In this review, aspects of the anatomy, physiology and pharmacology of the mesencephalic-frontal cortical dopamine system as they may relate to schizophrenia are described, and evidence for altered dopaminergic neurotransmission in the frontal cortex of schizophrenic patients is presented.
基于临床、神经心理学和神经影像学研究的观察结果，人们怀疑精神分裂症患者的前额叶皮质（PFC）存在功能障碍。由于PFC接受密集的多巴胺能神经支配，因此有人提出中脑皮质多巴胺系统异常可能导致精神分裂症的病理生理过程。在这篇综述中，我们描述了中脑-额叶皮质多巴胺系统在解剖学、生理学和药理学方面可能与精神分裂症相关的内容，并展示了精神分裂症患者额叶皮质多巴胺能神经传递改变的证据。
