Basden K, Cooper D W, Deane E M
Department of Biological Sciences, University of Western Sydney, Nepean, Kingswood, NSW, Australia.
Reprod Fertil Dev. 1997;9(2):243-54. doi: 10.1071/r96032.
A study has been made of the development of four lymphoid tissues from birth to maturity in the tammar wallaby Macropus eugenii--the cervical and thoracic thymus, lymph nodes and gut-associated lymphoid tissue (GALT). The development of these tissues in the tammar wallaby is similar to that in two other marsupials, the quokka Setonix brachyurus and the Virginian opossum Didelphis virginiana. Lymphocytes were first detected in the cervical thymus of the tammar at Day 2 post partum and in the thoracic thymus at Day 6. They were subsequently detected in lymph nodes at Day 4 and in the spleen by Day 12 but were not apparent in the GALT until around Day 90 post partum. By Day 21, the cervical thymus had developed distinct areas of cortex and medulla and Hassall's corpuscles were apparent. The maturation of other tissues followed with Hassall's corpuscles in the thoracic thymus by Day 30 and nodules and germinal centres in the lymph nodes by Day 90. Measurement of immunoglobulin G concentrations in the serum of young animals indicated a rise in titre around Day 90 post partum, correlating with the apparent maturation of the lymphoid tissues.
一项针对帚尾袋貂（Macropus eugenii）从出生到成熟阶段四种淋巴组织发育情况的研究展开，这四种淋巴组织分别是颈胸腺和胸胸腺、淋巴结以及肠道相关淋巴组织（GALT）。帚尾袋貂中这些组织的发育情况与另外两种有袋动物——短尾矮袋鼠（Setonix brachyurus）和弗吉尼亚负鼠（Didelphis virginiana）相似。产后第2天在帚尾袋貂的颈胸腺中首次检测到淋巴细胞，第6天在胸胸腺中检测到。随后在第4天于淋巴结中检测到，第12天在脾脏中检测到，但直到产后约第90天才在肠道相关淋巴组织中明显出现。到第21天，颈胸腺已发育出明显的皮质和髓质区域，且哈氏小体清晰可见。其他组织随后逐渐成熟，胸胸腺中的哈氏小体在第30天出现，淋巴结中的小结和生发中心在第90天出现。对幼龄动物血清中免疫球蛋白G浓度的测量表明，产后第90天左右抗体滴度上升，这与淋巴组织的明显成熟相关。
