Shen W, Cai X, Zhang D, Zhang X, Zheng A, Gong L
Department of Cardiology, Rui Jin Hospital, Shanghai Second Medical University.
Chin Med J (Engl). 1996 May;109(5):376-80.
To assess coronary flow reserve using a computer-assisted method with intracoronary papaverine in patients with angina pectoris.
Coronary arterial diameter, cross-sectional area and blood flow velocity were measured during coronary arteriography before and after intracoronary papaverine in 26 control subjects, 45 patients with significant coronary artery disease (> 50% luminal narrowing), 16 patients with syndrome X and 14 patients with hypertension and left ventricular hypertrophy (LVH).
After intracoronary administration of papaverine, proximal diameter, cross-sectional area, blood velocity, flow volume and reserve capacity of both left anterior descending and right coronary arteries were lower in patients with significant coronary stenosis than in the controls. Despite similar changes in diameter and cross-sectional area, the blood velocity, flow volume and reserve capacity of the two vessels were also lower in patients with syndrome X than in the controls. In 14 patients with hypertension and LVH, although the blood velocity and flow volume were augmented for the two arteries and did not differ from those in the controls, the flow reserve was reduced because of higher baseline blood velocity and flow volume.
Coronary flow reserve is reduced in patients with coronary artery disease, syndrome X or hypertensive LVH, which may be related to abnormal changes at different levels of the coronary vasculature or resting flow states.
采用计算机辅助方法并使用冠状动脉内注射罂粟碱来评估心绞痛患者的冠状动脉血流储备。
在26名对照受试者、45名患有严重冠状动脉疾病（管腔狭窄>50%）的患者、16名X综合征患者以及14名患有高血压和左心室肥厚（LVH）的患者中，于冠状动脉内注射罂粟碱前后的冠状动脉造影期间测量冠状动脉直径、横截面积和血流速度。
冠状动脉内注射罂粟碱后，严重冠状动脉狭窄患者左前降支和右冠状动脉的近端直径、横截面积、血流速度、血流量和储备能力均低于对照组。尽管X综合征患者的直径和横截面积变化相似，但其两条血管的血流速度、血流量和储备能力也低于对照组。在14名患有高血压和LVH的患者中，尽管两条动脉的血流速度和血流量增加且与对照组无差异，但由于基线血流速度和血流量较高，血流储备降低。
冠状动脉疾病、X综合征或高血压性LVH患者的冠状动脉血流储备降低，这可能与冠状动脉血管系统不同水平的异常变化或静息血流状态有关。
