Stenbygaard L E, Sørensen J B, Olsen J E
Department of Oncology, Copenhagen University Hospital Herlev, Denmark.
Acta Oncol. 1997;36(3):301-6. doi: 10.3109/02841869709001267.
A cohort of 259 consecutive patients with non-resectable adenocarcinoma of the lung (ACL) received chemotherapy and were followed until death with 124 cases examined by autopsy (autopsy rate 48%). Metastatic sites were identified and the following localisations were affected in 40% or more of patients post mortem: lungs, mediastinal lymph nodes, liver, pleura, adrenals, brain, and bones. Significant more metastatic sites were observed in patients who responded to the chemotherapy compared with non-responders (p = 0.04), in patients aged below the median of 58 years compared with older patients (p = 0.002), and, as expected, in patients with initial extensive disease compared with limited disease (p = 0.03). In contrast, no differences in metastatic pattern at autopsy could be detected with regard to other variables, such as initial TNM-stages, degree of histological differentiation, histologic subtypes, performance status, or LDH.
一组连续的259例不可切除的肺腺癌（ACL）患者接受了化疗，并随访至死亡，其中124例进行了尸检（尸检率48%）。确定了转移部位，以下部位在死后40%或更多患者中受到影响：肺、纵隔淋巴结、肝、胸膜、肾上腺、脑和骨。与无反应者相比，化疗有反应的患者观察到更多的转移部位（p = 0.04）；与年龄较大的患者相比，年龄低于58岁中位数的患者转移部位更多（p = 0.002）；正如预期的那样，与初始疾病局限的患者相比，初始疾病广泛的患者转移部位更多（p = 0.03）。相比之下，在尸检时，就其他变量而言，如初始TNM分期、组织学分化程度、组织学亚型、体能状态或乳酸脱氢酶，未检测到转移模式的差异。
