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1
Mck1, a member of the glycogen synthase kinase 3 family of protein kinases, is a negative regulator of pyruvate kinase in the yeast Saccharomyces cerevisiae.Mck1是蛋白激酶糖原合酶激酶3家族的成员之一，是酿酒酵母中丙酮酸激酶的负调节因子。
J Bacteriol. 1997 Jul;179(13):4415-8. doi: 10.1128/jb.179.13.4415-4418.1997.
2
MDS1, a dosage suppressor of an mck1 mutant, encodes a putative yeast homolog of glycogen synthase kinase 3.MDS1是mck1突变体的剂量抑制因子，编码糖原合酶激酶3的假定酵母同源物。
Mol Cell Biol. 1994 Jan;14(1):831-9. doi: 10.1128/mcb.14.1.831-839.1994.
3
Yeast glycogen synthase kinase 3 is involved in protein degradation in cooperation with Bul1, Bul2, and Rsp5.酵母糖原合酶激酶3与Bul1、Bul2和Rsp5协同参与蛋白质降解。
Mol Cell Biol. 2000 Sep;20(18):6712-20. doi: 10.1128/MCB.20.18.6712-6720.2000.
4
Direct and novel regulation of cAMP-dependent protein kinase by Mck1p, a yeast glycogen synthase kinase-3.酵母糖原合酶激酶-3（Mck1p）对环磷酸腺苷（cAMP）依赖性蛋白激酶的直接且新颖的调控
J Biol Chem. 2002 May 10;277(19):16814-22. doi: 10.1074/jbc.M112349200. Epub 2002 Mar 4.
5
Yeast MCK1 protein kinase autophosphorylates at tyrosine and serine but phosphorylates exogenous substrates at serine and threonine.酵母MCK1蛋白激酶在酪氨酸和丝氨酸位点进行自身磷酸化，但在丝氨酸和苏氨酸位点对外源底物进行磷酸化。
J Biol Chem. 1993 Oct 5;268(28):21155-64.
6
GSK-3 kinase Mck1 and calcineurin coordinately mediate Hsl1 down-regulation by Ca2+ in budding yeast.糖原合成酶激酶3（GSK-3）家族的Mck1激酶和钙调神经磷酸酶协同介导出芽酵母中Ca2+所致的Hsl1下调。
EMBO J. 2001 Mar 1;20(5):1074-85. doi: 10.1093/emboj/20.5.1074.
7
A suppressor of a centromere DNA mutation encodes a putative protein kinase (MCK1).着丝粒DNA突变的一个抑制因子编码一种假定的蛋白激酶（MCK1）。
Genes Dev. 1991 Apr;5(4):549-60. doi: 10.1101/gad.5.4.549.
8
The Mck1 GSK-3 kinase inhibits the activity of Clb2-Cdk1 post-nuclear division.Mck1 GSK-3 激酶抑制核分裂后 Clb2-Cdk1 的活性。
Cell Cycle. 2012 Sep 15;11(18):3421-32. doi: 10.4161/cc.21731. Epub 2012 Aug 23.
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The Kluyveromyces lactis gene KLGSK-3 combines functions which in Saccharomyces cerevisiae are performed by MCK1 and MSD1.乳酸克鲁维酵母基因KLGSK - 3兼具酿酒酵母中由MCK1和MSD1执行的功能。
Curr Genet. 1998 Apr;33(4):262-7. doi: 10.1007/s002940050335.
10
The yeast MCK1 gene encodes a protein kinase homolog that activates early meiotic gene expression.酵母MCK1基因编码一种蛋白激酶同源物，该同源物可激活减数分裂早期基因表达。
Genes Dev. 1991 Apr;5(4):533-48. doi: 10.1101/gad.5.4.533.

引用本文的文献

1
The interactome of the Bakers' yeast peroxiredoxin Tsa1 implicates it in the redox regulation of intermediary metabolism, glycolysis and zinc homeostasis.面包酵母过氧化物还原酶Tsa1的相互作用组表明它参与中间代谢、糖酵解和锌稳态的氧化还原调节。
bioRxiv. 2025 Feb 21:2025.02.18.638137. doi: 10.1101/2025.02.18.638137.
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Mck1 kinase is a new player in the DNA damage checkpoint pathway.Mck1激酶是DNA损伤检查点通路中的一个新成员。
PLoS Genet. 2019 Oct 31;15(10):e1008372. doi: 10.1371/journal.pgen.1008372. eCollection 2019 Oct.
3
Cdc6 degradation requires phosphodegron created by GSK-3 and Cdk1 for SCFCdc4 recognition in Saccharomyces cerevisiae.在酿酒酵母中，Cdc6的降解需要由GSK-3和Cdk1产生的磷酸化降解结构域，以便SCFCdc4识别。
Mol Biol Cell. 2015 Jul 15;26(14):2609-19. doi: 10.1091/mbc.E14-07-1213. Epub 2015 May 20.
4
In silico evidence for functional specialization after genome duplication in yeast.酵母基因组复制后功能特化的计算机模拟证据。
FEMS Yeast Res. 2009 Feb;9(1):16-31. doi: 10.1111/j.1567-1364.2008.00451.x.
5
Effects of the human papilloma virus HPV-16 E7 oncoprotein on glycolysis and glutaminolysis: role of pyruvate kinase type M2 and the glycolytic-enzyme complex.人乳头瘤病毒HPV-16 E7癌蛋白对糖酵解和谷氨酰胺分解的影响：M2型丙酮酸激酶和糖酵解酶复合物的作用
Biochem J. 2001 May 15;356(Pt 1):247-56. doi: 10.1042/0264-6021:3560247.
6
Shared roles of yeast glycogen synthase kinase 3 family members in nitrogen-responsive phosphorylation of meiotic regulator Ume6p.酵母糖原合酶激酶3家族成员在减数分裂调节因子Ume6p的氮响应磷酸化中的共同作用。
Mol Cell Biol. 2000 Aug;20(15):5447-53. doi: 10.1128/MCB.20.15.5447-5453.2000.
7
The dual-specificity protein phosphatase Yvh1p acts upstream of the protein kinase mck1p in promoting spore development in Saccharomyces cerevisiae.双特异性蛋白磷酸酶Yvh1p在促进酿酒酵母孢子发育过程中，作用于蛋白激酶mck1p的上游。
J Bacteriol. 1999 Sep;181(17):5219-24. doi: 10.1128/JB.181.17.5219-5224.1999.

本文引用的文献

1
GSK3: a SHAGGY frog story.糖原合成酶激酶3：一个杂乱无章的故事。
Trends Cell Biol. 1996 Jul;6(7):274-9. doi: 10.1016/0962-8924(96)10023-4.
2
Yeast MCK1 protein kinase autophosphorylates at tyrosine and serine but phosphorylates exogenous substrates at serine and threonine.酵母MCK1蛋白激酶在酪氨酸和丝氨酸位点进行自身磷酸化，但在丝氨酸和苏氨酸位点对外源底物进行磷酸化。
J Biol Chem. 1993 Oct 5;268(28):21155-64.
3
The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.视网膜母细胞瘤蛋白与1型蛋白磷酸酶催化亚基相关联。
Genes Dev. 1993 Apr;7(4):555-69. doi: 10.1101/gad.7.4.555.
4
MDS1, a dosage suppressor of an mck1 mutant, encodes a putative yeast homolog of glycogen synthase kinase 3.MDS1是mck1突变体的剂量抑制因子，编码糖原合酶激酶3的假定酵母同源物。
Mol Cell Biol. 1994 Jan;14(1):831-9. doi: 10.1128/mcb.14.1.831-839.1994.
5
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.p21 Cdk相互作用蛋白Cip1是G1期细胞周期蛋白依赖性激酶的有效抑制剂。
Cell. 1993 Nov 19;75(4):805-16. doi: 10.1016/0092-8674(93)90499-g.
6
Overexpression of the yeast MCK1 protein kinase suppresses conditional mutations in centromere-binding protein genes CBF2 and CBF5.酵母MCK1蛋白激酶的过表达可抑制着丝粒结合蛋白基因CBF2和CBF5中的条件性突变。
Mol Gen Genet. 1995 Feb 6;246(3):360-6. doi: 10.1007/BF00288609.
7
The yeast immunophilin Fpr3 is a physiological substrate of the tyrosine-specific phosphoprotein phosphatase Ptp1.酵母亲免蛋白Fpr3是酪氨酸特异性磷酸蛋白磷酸酶Ptp1的生理底物。
J Biol Chem. 1995 Oct 20;270(42):25185-93. doi: 10.1074/jbc.270.42.25185.
8
A positive selection for mutants lacking orotidine-5'-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance.酵母中缺乏乳清苷-5'-磷酸脱羧酶活性的突变体的正向选择：5-氟乳清酸抗性。
Mol Gen Genet. 1984;197(2):345-6. doi: 10.1007/BF00330984.
9
The isolation, characterization, and sequence of the pyruvate kinase gene of Saccharomyces cerevisiae.酿酒酵母丙酮酸激酶基因的分离、特性鉴定及序列分析
J Biol Chem. 1983 Feb 25;258(4):2193-201.
10
Design of glycolysis.糖酵解的设计
Philos Trans R Soc Lond B Biol Sci. 1981 Jun 26;293(1063):5-22. doi: 10.1098/rstb.1981.0056.

Mck1是蛋白激酶糖原合酶激酶3家族的成员之一，是酿酒酵母中丙酮酸激酶的负调节因子。

Mck1, a member of the glycogen synthase kinase 3 family of protein kinases, is a negative regulator of pyruvate kinase in the yeast Saccharomyces cerevisiae.

作者信息

Brazill D T, Thorner J, Martin G S

机构信息

Department of Molecular and Cell Biology, University of California at Berkeley, 94720, USA.

出版信息

J Bacteriol. 1997 Jul;179(13):4415-8. doi: 10.1128/jb.179.13.4415-4418.1997.

DOI:10.1128/jb.179.13.4415-4418.1997
PMID:9209064
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC179270/
Abstract

An interaction between the Saccharomyces cerevisiae protein kinase Mck1 and pyruvate kinase (Pyk1) was detected by using the two-hybrid method. Purified Mck1 was able to phosphorylate purified Pyk1 on Ser in vitro. Pyruvate kinase activity was elevated in mck1 delta cells. Several of the phenotypes of mck1 delta mutants are similar to those observed in cells overexpressing PYK1. Co-overexpression of MCK1 suppressed all of the phenotypes associated with PYK1 overexpression. These results indicate that Mck1 negatively regulates pyruvate kinase activity, possibly by direct phosphorylation.

摘要

利用双杂交方法检测到酿酒酵母蛋白激酶Mck1与丙酮酸激酶（Pyk1）之间存在相互作用。纯化的Mck1能够在体外将纯化的Pyk1的丝氨酸残基磷酸化。在mck1Δ细胞中丙酮酸激酶活性升高。mck1Δ突变体的几种表型与在过表达PYK1的细胞中观察到的表型相似。MCK1的共过表达抑制了与PYK1过表达相关的所有表型。这些结果表明，Mck1可能通过直接磷酸化对丙酮酸激酶活性进行负调控。